Propofol or midazolam - which is best for the sedation of adult ventilated patients in intensive care units? A systematic review

Simple item page
dc.contributor.authorMagarey, J.
dc.date.issued2001
dc.descriptionCopyright © 2001 Published by Elsevier B.V.
dc.description.abstractIntensive care patients are commonly sedated to maintain comfort and to facilitate life saving therapy. Although sedation is ordered by medical staff, nurses are usually responsible for its administration and titration and thus the question of which drug regime should be chosen is an important practice issue for nurses (1,2). This paper is a report on a systematic review that was conducted to compare the effectiveness of two of the most common drugs used for the sedation of adult ventilated patients in Australian intensive care units (ICUs)--propofol and midazolam (3). All randomised controlled trials (RCTs) which compared propofol with midazolam for the sedation of adult ventilated patients in ICUs were included in the study. The outcome measures evaluated were the quality of sedation achieved, the length of time from cessation of sedation till extubation, recovery time, duration of admission to the ICU and the incidence of haemodynamic complications. Meta-analysis was used to compare results of studies where subjects had the same characteristics and the outcome criteria were measured in the same manner. The review found that infusions of both midazolam and propofol appear to provide similar quality sedation, that extubation time and recovery time is shorter in patients sedated with propofol and that haemodynamic complications related to either drug regime are not usually clinically significant.
dc.description.statementofresponsibilityJudith M Magarey
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/710660/description#description
dc.identifier.citationAustralian Critical Care, 2001; 14(4):147-154
dc.identifier.doi10.1016/S1036-7314(05)80056-6
dc.identifier.issn1036-7314
dc.identifier.orcidMagarey, J. [0000-0002-6150-2894]
dc.identifier.urihttp://hdl.handle.net/2440/14602
dc.language.isoen
dc.publisherCambridge Media
dc.source.urihttps://doi.org/10.1016/s1036-7314(05)80056-6
dc.subjectHumans
dc.subjectPropofol
dc.subjectMidazolam
dc.subjectHypnotics and Sedatives
dc.subjectRespiration, Artificial
dc.subjectCritical Care
dc.subjectNursing Care
dc.subjectAdult
dc.subjectIntensive Care Units
dc.titlePropofol or midazolam - which is best for the sedation of adult ventilated patients in intensive care units? A systematic review
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Nursing publications