Novel epigallocatechin-3-gallate (EGCG)-loaded mesoporous bioglass scaffolds for bone recruitment applications
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Date
2021
Authors
Ou, S.F.
Tsao, Y.L.
Lin, W.C.
Wang, Y.T.
Wang, L.
Fan, F.Y.
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Applied Sciences, 2021; 11(1, article no. 243):1-9
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Bioglass-based material has been widely used in the field of biomedical science. In this study, the proper concentration of epigallocatechin-3-gallate (EGCG) for a mesoporous bioglass (MBG) scaffold was determined based on the sponge replication method. The fabrication procedure performed using a foam exchange technique resulted in an interconnected network of pores scaffolds with no cracks. In the minimum bactericidal concentrations of the bacteria assessed, the antibacterial concentration of EGCG against E. coli (200 µg/mL) was higher than that against S. aureus (25 µg/mL). The MBG and EGCG-MBG scaffolds exhibited excellent apatite mineralization and drug release abilities (the highest cumulative drug release from the EGCG-MBG scaffold was 75.37%). Thus, a 200 µg/mL EGCG can prevent cell apoptosis and directly enhance cell proliferation. Hence, a low-dose EGCGMBG scaffold is another option for bone recruitment material.
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Copyright 2021 The author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (https://creativecommons.org/licenses/by/4.0/)