Amphibian antimicrobial peptides : their structures and mechanisms of action / by Brian Cheng San Chia.
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Date
2000
Authors
Chia, Brian Cheng San
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Abstract
Three antimicrobial peptides, maculatin 1.1, uperin 3.6 and caerin 4.1 have been isolated from the respective skin glands of the Australian amphibians Litoria genimaculata, Uperoleia mjobergii and Litoria caerulea. To gain a deeper insight into their mechanisms of action, three dimensional structural studies have been conducted using circular dichroism, two-dimensional nuclear resonance and computer modelling techniques. The role of central flexibility within antibiotic peptides in their interaction with bacterial membranes is also discussed.
School/Discipline
Dept. of Chemistry
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2000
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Copy of author's previously published works inserted.
Bibliography: leaves 183-220.
xiii, 226 leaves : ill. (chiefly col.) ; 30 cm.
Bibliography: leaves 183-220.
xiii, 226 leaves : ill. (chiefly col.) ; 30 cm.