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A direct and non-invasive method for kidney delivery of therapeutics in mice

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dc.contributor.authorPavathuparambil Abdul Manaph, N.
dc.contributor.authorAl Hawwas, M.
dc.contributor.authorZhou, X.F.
dc.date.issued2018
dc.description.abstractKidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. Kidney malfunction can be fatal and the renal research administers testing pharmaceutical agents or stem cells in rodents to study their therapeutic efficacy. However, targeted delivery of agents into mice kidney is strenuous and may require laparotomy. Here we present a direct delivery method for cell transplantation or drug injection into the mice kidney. The method is simple and can be performed non-invasively with avoidance of surgical intervention on the animals. Nevertheless, this method serves as an efficient method for in vivo drug delivery or engraftment studies for renal research.
dc.identifier.citationMethodsX, 2018; 5:1440-1446
dc.identifier.doi10.1016/j.mex.2018.10.019
dc.identifier.issn2215-0161
dc.identifier.issn2215-0161
dc.identifier.orcidZhou, X.F. [0000-0002-8687-0175]
dc.identifier.urihttps://hdl.handle.net/11541.2/135089
dc.language.isoen
dc.publisherElsevier
dc.relation.fundingUniversity of South Australia
dc.relation.fundingD&R Pharmaceutics China
dc.rightsCopyright 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license 4.0 (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1016/j.mex.2018.10.019
dc.subjectkidney
dc.subjectdrugs
dc.subjectdelivery
dc.subjectsurgery
dc.subjectinjection
dc.subjectDirection injection into mice kidney
dc.titleA direct and non-invasive method for kidney delivery of therapeutics in mice
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12167924950001831 13167924940001831 1-s2.0-S2215016118301766-main.pdf
ror.mmsid9916242400301831

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