Identification of common and distinct pathways in inflammatory bowel disease and colorectal cancer: a hypothesis based on weighted gene co-expression network analysis
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Date
2022
Authors
Derakhshani, A.
Javadrashid, D.
Hemmat, N.
Dufour, A.
Solimando, A.G.
Abdoli Shadbad, M.
Duijf, P.H.G.
Brunetti, O.
Silvestris, N.
Baradaran, B.
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Frontiers in Genetics, 2022; 13(848646):1-12
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Abstract
Patients with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, are at higher risk to develop colorectal cancer (CRC). However, the underlying mechanisms of this predisposition remain elusive. We performed in-depth comparative computational analyses to gain new insights, including weighted gene co-expression network analysis (WGCNA) and gene ontology and pathway enrichment analyses, using gene expression datasets from IBD and CRC patients. When individually comparing IBD and CRC to normal control samples, we identified clusters of highly correlated genes, differentially expressed genes, and module-trait associations specific for each disease. When comparing IBD to CRC, we identified common hub genes and commonly enriched pathways. Most notably, IBD and CRC share significantly increased expression of five genes (MMP10, LCN2, REG1A, REG3A, and DUOX2), enriched inflammatory and neutrophil activation pathways and, most notably, highly significant enrichment of IL-4 and IL-13 signaling. Thus, our work expands our knowledge about the intricate relationship between IBD and CRC development and provides new rationales for developing novel therapeutic strategies.
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Data source: Supplementary Material, https://doi.org/10.3389/fgene.2022.848646
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Copyright 2022 Derakhshani, Javadrashid, Hemmat, Dufour, Solimando, Abdoli Shadbad, Duijf, Brunetti, Silvestris and Baradaran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. (http://creativecommons.org/licenses/by/4.0/)