Polyphenols and glycémie control

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dc.contributor.authorKim, Y.A.
dc.contributor.authorKeogh, J.B.
dc.contributor.authorClifton, P.M.
dc.date.issued2016
dc.description.abstractGrowing evidence from animal studies supports the anti-diabetic properties of some dietary polyphenols, suggesting that dietary polyphenols could be one dietary therapy for the prevention and management of Type 2 diabetes. This review aims to address the potential mechanisms of action of dietary polyphenols in the regulation of glucose homeostasis and insulin sensitivity based on in vitro and in vivo studies, and to provide a comprehensive overview of the anti-diabetic effects of commonly consumed dietary polyphenols including polyphenol-rich mixed diets, tea and coffee, chocolate and cocoa, cinnamon, grape, pomegranate, red wine, berries and olive oil, with a focus on human clinical trials. Dietary polyphenols may inhibit α-amylase and α-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1 (SGLT1), stimulate insulin secretion and reduce hepatic glucose output. Polyphenols may also enhance insulin-dependent glucose uptake, activate 5' adenosine monophosphate-activated protein kinase (AMPK), modify the microbiome and have anti-inflammatory effects. However, human epidemiological and intervention studies have shown inconsistent results. Further intervention studies are essential to clarify the conflicting findings and confirm or refute the anti-diabetic effects of dietary polyphenols.
dc.description.statementofresponsibilityYoona Kim, Jennifer B. Keogh and Peter M. Clifton
dc.identifier.citationNutrients, 2016; 8(1):17-17
dc.identifier.doi10.3390/nu8010017
dc.identifier.issn2072-6643
dc.identifier.issn2072-6643
dc.identifier.orcidClifton, P.M. [0000-0002-6411-626X]
dc.identifier.urihttps://hdl.handle.net/2440/138425
dc.language.isoen
dc.publisherMDPI
dc.relation.grantNHMRC
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/nu8010017
dc.subjectdietary polyphenols; insulin sensitivity; glucose homeostasis; clinical trials
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshPlants, Edible
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshInsulin Resistance
dc.subject.meshInsulin
dc.subject.meshGlucose
dc.subject.meshPlant Extracts
dc.subject.meshDiet
dc.subject.meshPolyphenols
dc.subject.meshMagnoliopsida
dc.titlePolyphenols and glycémie control
dc.title.alternativePolyphenols and glycemie control
dc.typeJournal article
pubs.publication-statusPublished

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