Siglec-10 expression is up-regulated in activated human CD4⁺ T cells
Date
2020
Authors
Bandala-Sanchez, E.
Bediaga, N.G.
Naselli, G.
Neale, A.M.
Harrison, L.C.
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Journal article
Citation
Human Immunology, 2020; 81(2-3):101-104
Statement of Responsibility
E. Bandala-Sanchez, N.G. Bediaga, G. Naselli, A.M. Neale, L.C. Harrison
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Abstract
Most sialic acid–binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we examined the expression of Siglec-10 at the RNA and protein level in human CD4+ T cells. Analysis by RNAseq, qPCR and flow cytometry demonstrated that, in contrast to other Siglecs, after activation of CD4+ T cells Siglec-10 was selectively upregulated in a subset of cells also high for CD52 expression. This observation is consistent with a homeostatic role for Siglec-10 in human CD4+ T cells.
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© 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.