Benign neonatal sleep myoclonus: an autosomal dominant form not allelic to KCNQ2 or KCNQ3
Date
2012
Authors
Afawi, Z.
Bassan, H.
Heron, S.
Oliver, K.
Straussberg, R.
Scheffer, I.
Leventer, R.
Korczyn, A.
Berkovic, S.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Child Neurology, 2012; 27(10):1260-1263
Statement of Responsibility
Zaid Afawi, Haim Bassan, Sarah Heron, Karen Oliver, Rachel Straussberg, Ingrid Scheffer, Richard Leventer, Amos Korczyn and Samuel Berkovic
Conference Name
Abstract
Benign neonatal sleep myoclonus is an uncommon, nonepileptic disorder characterized by myoclonic jerks appearing in the neonatal period that occur predominantly during sleep. Although self-limiting, the disorder is frequently confused with epileptic neonatal seizures. A few familial cases have been reported; however the genetics has not been studied. We ascertained 3 families with 2 or more affected individuals and analyzed the pedigrees. We used microsatellite markers to determine if the disorder was possibly linked to KCNQ2 or KCNQ3, the 2 genes that cause most cases of benign familial neonatal seizures, a disorder that it could be easily confused with. The 3 pedigrees, including one with 4 affected individuals, were suggestive of autosomal dominant inheritance. The loci for KCNQ2 and KCNQ3 were excluded in the 2 larger families. We conclude that benign neonatal sleep myoclonus can show autosomal dominant inheritance and is not allelic with benign familial neonatal seizures.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© The Author(s) 2012