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The development of the pulmonary surfactant system in California sea lions

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dc.contributor.authorMiller, N.
dc.contributor.authorPostle, A.
dc.contributor.authorSchurch, S.
dc.contributor.authorSchoel, W.
dc.contributor.authorDaniels, C.B.
dc.contributor.authorOrgeig, S.
dc.date.issued2005
dc.description.abstractPulmonary surfactant has previously been shown to change during development, both in composition and function. Adult pinnipeds, unlike adult terrestrial mammals, have an altered lung physiology to cope with the high pressures associated with deep diving. Here, we investigated how surfactant composition and function develop in California sea lions (Zalophus californianus). Phosphatidylinositol was the major anionic phospholipid in the newborn, whereas phosphatidylglycerol was increased in the adult. This increase in phosphatidylglycerol occurred at the expense of phosphatidylinositol and phosphatidylserine. There was a shift from long chain and polyunsaturated phospholipid molecular species in the newborn to shorter chain and mono- and disaturated molecular species in the adult. Cholesterol and SP-B concentrations were also higher in the adult. Adult surfactant could reach a lower equilibrium surface tension, but newborn surfactant could reach a lower minimum surface tension. The composition and function of surfactant from newborn California sea lions suggest that this age group is similar to terrestrial newborn mammals, whereas the adult has a "diving mammal" surfactant that can aid the lung during deep dives. The onset of diving is probably a trigger for surfactant development in these animals.
dc.identifier.citationComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 2005; 141(2):191-199
dc.identifier.doi10.1016/j.cbpb.2005.05.035
dc.identifier.issn1095-6433
dc.identifier.issn1531-4332
dc.identifier.urihttps://hdl.handle.net/1959.8/46169
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1016/j.cbpb.2005.05.035
dc.subjectLung
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectSea Lions
dc.subjectCholesterol
dc.subjectPhospholipids
dc.subjectPulmonary Surfactant-Associated Protein A
dc.subjectPulmonary Surfactant-Associated Protein B
dc.subjectPulmonary Surfactants
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectSpectrometry, Mass, Electrospray Ionization
dc.subjectSurface Tension
dc.subjectFemale
dc.subjectMale
dc.titleThe development of the pulmonary surfactant system in California sea lions
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915911754601831

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