Evaluation of lacrimation characteristics in clinically normal New Zealand White rabbits by using the Schirmer Tear Test I

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dc.contributor.authorWhittaker, A.
dc.contributor.authorWilliams, D.
dc.date.issued2015
dc.description.abstractRabbits are a common animal model in eye research and in safety testing of novel chemical agents. In addition, ocular disease is a routine presentation in clinical practice. However, few studies have quantitatively examined lacrimation kinetics in this species. This study used a noninvasive method of tear measurement (the Schirmer tear test, STT) to quantify values for basal and reflex tearing and to determine the kinetic nature of tear production in 76 New Zealand white rabbits. We obtained a value of 7.58 ± 2.3 mm/min for the standard 1-min STT. Calculated values for mean residual tear volume and reflex tear flow were 1.95 μL and 0.035 μL/s, respectively. In addition, this study provides preliminary evidence for an interaction effect between eyes given that higher STT values were obtained from the second eye tested.
dc.description.statementofresponsibilityAlexandra L Whittaker and David L Williams
dc.identifier.citationJournal of the American Association for Laboratory Animal Science, 2015; 54(6):783-787
dc.identifier.issn1559-6109
dc.identifier.issn2769-6677
dc.identifier.urihttp://hdl.handle.net/2440/96921
dc.language.isoen
dc.publisherAmerican Association for Laboratory Animal Science
dc.rightsCopyright 2015 by the American Association for Laboratory Animal Science.
dc.subjectLacrimal Apparatus
dc.subjectTears
dc.subjectAnimals
dc.subjectRabbits
dc.subjectEye Diseases
dc.subjectDisease Models, Animal
dc.subjectReagent Strips
dc.subjectReflex
dc.titleEvaluation of lacrimation characteristics in clinically normal New Zealand White rabbits by using the Schirmer Tear Test I
dc.typeJournal article
pubs.publication-statusPublished

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