Altered Insulin-Like Growth Factor binding Proteins
Date
2008
Authors
Forbes, B.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Patent
Citation
Statement of Responsibility
Invented by B. E. Forbes; Assigned to The University of Adelaide; A.P.T. Patent and Trade Mark Attorneys agents for inventor.
Conference Name
Abstract
Disclosed are altered Insulin-like Growth Factor Binding Protein molecules able to effect binding of IGF-I or IGF-II with high affinity characterised in having an inhibited release of IGF on contact with extracellular matrix and exposure to a protease. Also disclosed are nucleic acids encoding the altered IGFBP molecules, a host cell carrying that nucleic acid, and methods of reducing IGF mediated proliferation of a population of cancerous cells.
School/Discipline
Dissertation Note
Provenance
Description
PATENT: B. E. Forbes (Assignee: The University of Adelaide). NZ 537556 (PCT/AU2003/000898) filed Jan. 10, 2005; published Jul. 31, 2008; expires Jul. 11, 2023