Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity
Date
2012
Authors
Bell, S.
McMillan, J.
Yorke, J.
Kavanagh, E.
Johnson, E.
Wong, L.
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Journal article
Citation
Chemical Communications, 2012; 48(95):11692-11694
Statement of Responsibility
Stephen G. Bell, James H. C. McMillan, Jake A. Yorke, Emma Kavanagh, Eachan O. D. Johnson, and Luet-Lok Wong
Conference Name
Abstract
A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known.
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© Royal Society of Chemistry 2012