The impact of genetic predictors of opioid dependence on neuroimmune and endocrine markers in healthy adults /
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(Published version)
Date
2015
Authors
Kershaw, Stephanie,
Editors
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Type:
thesis
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Abstract
Genetic variations within the endogenous opioid, innate immune and neurological pathways have been associated with an increased risk of opioid dependence. These variations could potentially have an impact on any of the stages of opioid dependence, including the initial response to opioid administration. However, to date the consequences of these variations on the physiological and psychological response to acute opioid administration have not been investigated. This study aimed to assess the impact of single nucleotide polymorphisms (SNPs) in the Interleukin 1B (IL1B) (rs#16944 and rs#1143627), Dopamine Receptor 2 (DRD2) (rs#1076560) and μ-Opioid Receptor (OPRM1) (rs#1799971) genes on the acute response to opioid administration.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD)--University of South Australia, 2015.
Provenance
Copyright 2015 Stephanie Kershaw.
Description
1 ethesis (xxiv, 287 pages) :
illustrations.
Includes bibliographical references (pages 230-272)
illustrations.
Includes bibliographical references (pages 230-272)
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506 0#$fstar $2Unrestricted online access