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Cohort profile: the Melbourne Collaborative Cohort Study (Health 2020)

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dc.contributor.authorMilne, R.L.
dc.contributor.authorFletcher, A.S.
dc.contributor.authorMacInnis, R.J.
dc.contributor.authorHodge, A.M.
dc.contributor.authorHopkins, A.H.
dc.contributor.authorBassett, J.K.
dc.contributor.authorBruinsma, F.J.
dc.contributor.authorLynch, B.M.
dc.contributor.authorDugué, P.A.
dc.contributor.authorJayasekara, H.
dc.contributor.authorBrinkman, M.T.
dc.contributor.authorPopowski, L.V.
dc.contributor.authorBaglietto, L.
dc.contributor.authorSeveri, G.
dc.contributor.authorO'Dea, K.
dc.contributor.authorHopper, J.L.
dc.contributor.authorSouthey, M.C.
dc.contributor.authorEnglish, D.R.
dc.contributor.authorGiles, G.G.
dc.date.issued2017
dc.description.abstractThe Melbourne Collaborative Cohort Study (MCCS), also known as Health 2020, was planned in the late 1980s and established in the early 1990s as an omnibus cohort to investigate prospectively the roles of diet and lifestyle in causing cancer and other non-communicable diseases. It was developed contemporaneously with the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 2 at a time when diet and nutrition were considered important to cancer causation,3 but detailed information adequate to inform prevention was scant. The literature was dominated by inconsistent evidence generated by a large number of small case-control studies which had problems not only with statistical power and dietary assessment but also, more importantly, with forms of information bias to which such studies are prone. A prospective design was chosen to reduce these biases. We also considered that a contributing factor to the modest strengths of association between dietary factors and cancer observed by previous cohort studies, might be related to the limited range of dietary intakes within a given population. We sought ways in which we might address this and, as Melbourne had a relatively large number of migrants from Italy and Greece with distinct dietary and lifestyle differences from the majority of British descent, we deliberately targeted them for recruitment in order to broaden the range of observations of the measured lifestyle risk factors.
dc.identifier.citationInternational Journal of Epidemiology, 2017; 46(6):1757i-1757i
dc.identifier.doi10.1093/ije/dyx085
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.urihttps://hdl.handle.net/11541.2/130158
dc.language.isoen
dc.publisherOxford University Press
dc.relation.fundingCancer Council Victoria
dc.relation.fundingVicHealth
dc.relation.fundingNHMRC 209057
dc.relation.fundingNHMRC 251553
dc.relation.fundingNHMRC 504711
dc.relation.fundingVictorian Breast Cancer Research Consortium (VBCRC)
dc.rightsCopyright 2017 The Author(s) Access Condition Notes: This article is free to read online
dc.source.urihttps://doi.org/10.1093/ije/dyx085
dc.subjectMelbourne Collaborative Cohort Study
dc.subjectMCCS
dc.subjectHealth 2020
dc.subjectcancer
dc.subjectnon-communicable diseases
dc.titleCohort profile: the Melbourne Collaborative Cohort Study (Health 2020)
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916169310901831

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