TLR4-dependent claudin-1 internalization and secretagogue-mediated chloride secretion regulate irinotecan-induced diarrhea

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dc.contributor.authorWardill, H.
dc.contributor.authorBowen, J.
dc.contributor.authorVan Sebille, Y.
dc.contributor.authorSecombe, K.
dc.contributor.authorColler, J.
dc.contributor.authorBall, I.
dc.contributor.authorLogan, R.
dc.contributor.authorGibson, R.
dc.date.issued2016
dc.descriptionPublished OnlineFirst August 22, 2016
dc.description.abstractAbstract not available
dc.description.statementofresponsibilityHannah R.Wardill, Joanne M. Bowen, Ysabella Z.A. Van Sebille, Kate R. Secombe, Janet K. Coller, Imogen A. Ball, Richard M. Logan, and Rachel J Gibson
dc.identifier.citationMolecular Cancer Therapeutics, 2016; 15(11):2767-2779
dc.identifier.doi10.1158/1535-7163.MCT-16-0330
dc.identifier.issn1535-7163
dc.identifier.issn1538-8514
dc.identifier.orcidWardill, H. [0000-0002-6613-3661]
dc.identifier.orcidBowen, J. [0000-0003-0876-0031]
dc.identifier.orcidSecombe, K. [0000-0003-0716-238X]
dc.identifier.orcidColler, J. [0000-0002-8273-5048]
dc.identifier.orcidBall, I. [0000-0002-9629-9064]
dc.identifier.orcidLogan, R. [0000-0002-9331-1814]
dc.identifier.orcidGibson, R. [0000-0002-4796-1621]
dc.identifier.urihttp://hdl.handle.net/2440/104904
dc.language.isoen
dc.publisherAmerican Association for Cancer Research
dc.rights© 2016 American Association for Cancer Research.
dc.source.urihttps://doi.org/10.1158/1535-7163.mct-16-0330
dc.subjectIntestinal Mucosa
dc.subjectTight Junctions
dc.subjectIntracellular Space
dc.subjectAnimals
dc.subjectMice, Knockout
dc.subjectMice
dc.subjectDisease Models, Animal
dc.subjectDiarrhea
dc.subjectChlorides
dc.subjectCamptothecin
dc.subjectRNA, Messenger
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectGene Expression
dc.subjectProtein Transport
dc.subjectToll-Like Receptor 4
dc.subjectClaudin-1
dc.subjectTight Junction Proteins
dc.subjectIrinotecan
dc.titleTLR4-dependent claudin-1 internalization and secretagogue-mediated chloride secretion regulate irinotecan-induced diarrhea
dc.typeJournal article
pubs.publication-statusPublished

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