Effects of nitric oxide on aortic valve calcification in vitro
| dc.contributor.author | Hua, Xiang | en |
| dc.contributor.school | School of Medicine | en |
| dc.date.issued | 2007 | en |
| dc.description.abstract | Aortic stenosis is characterized by accelerated aortic valve calcification, but the pathogenesis of this process is poorly understood. The aim of this study was to evaluate the potential impact of nitric oxide supplementation on valve matrix calcification in a tissue culture model, and the interaction between superoxide anion release and the process. Data from the study suggest that superoxide anion release, induced by transforming growth factor beta 1 contributes to calcific formation and that nitric oxide can limit this process. | en |
| dc.description.dissertation | Thesis (M.Clin.Sc.) -- University of Adelaide, School of Medicine, 2007 | en |
| dc.identifier.uri | http://hdl.handle.net/2440/69462 | |
| dc.provenance | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals | |
| dc.subject | aortic valve abnormalities; calcification; nitric oxide | en |
| dc.title | Effects of nitric oxide on aortic valve calcification in vitro | en |
| dc.type | Thesis | en |