Accuracy of biopsy in subtyping periocular basal cell carcinoma

Simple item page
dc.contributor.authorSun, M.
dc.contributor.authorWu, A.
dc.contributor.authorHuilgo, S.
dc.contributor.authorSelva, D.
dc.date.issued2015
dc.description.abstractPURPOSE: To determine the accuracy of initial biopsy in the diagnosis of basal cell carcinoma (BCC) histologic subtype. METHODS: Retrospective histopathologic review of patients with a diagnosis of primary periocular BCC from 2006 to 2013 inclusive. RESULTS: A total of 174 primary BCCs were identified. BCCs were classified as nodular, superficial, or aggressive (including mixed cases with an aggressive component). Punch biopsies were used in 41% of cases, while the remaining patients underwent shave or incision biopsies. The final histologic subtypes at excision were nodular (59%), superficial (7%), nodular and superficial (7%), and aggressive (51%). The overall concordance between the BCC subtype identified in the biopsy specimen and the subsequent excision specimen was 54%. In total, there were 51 cases (29%) of BCC, which included aggressive subtypes, of which 52% of initial biopsies failed to detect an aggressive component. There were 45 cases (26%) of mixed BCC, and an aggressive histologic subtype was present in 73% of these cases. CONCLUSIONS: The accuracy of initial biopsy for BCC histologic subtype at excision is highest for nodular BCC. For aggressive BCC, biopsy was able to detect the aggressive component in only 48% of cases. This may have implications for choice of treatment modality.
dc.description.statementofresponsibilityMichelle T. Sun, Albert Wu, Shyamala C. Huilgol, and Dinesh Selva
dc.identifier.citationOphthalmic Plastic and Reconstructive Surgery, 2015; 31(6):449-451
dc.identifier.doi10.1097/iop.0000000000000372
dc.identifier.issn0740-9303
dc.identifier.issn1537-2677
dc.identifier.orcidSun, M. [0000-0002-8066-9278]
dc.identifier.orcidSelva, D. [0000-0002-2169-5417]
dc.identifier.urihttp://hdl.handle.net/2440/90358
dc.language.isoen
dc.publisherLippincott, Williams & Wilkins
dc.rightsCopyright © 2015 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
dc.source.urihttps://doi.org/10.1097/iop.0000000000000372
dc.subjectHumans
dc.subjectCarcinoma, Basal Cell
dc.subjectEyelid Neoplasms
dc.subjectSkin Neoplasms
dc.subjectBiopsy
dc.subjectRetrospective Studies
dc.subjectReproducibility of Results
dc.titleAccuracy of biopsy in subtyping periocular basal cell carcinoma
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Opthalmology & Visual Sciences publications