The natural history of scoliosis in females with rett syndrome

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dc.contributor.authorDowns, J.
dc.contributor.authorTorode, I.
dc.contributor.authorWong, K.
dc.contributor.authorEllaway, C.
dc.contributor.authorElliott, E.J.
dc.contributor.authorChristodoulou, J.
dc.contributor.authorJacoby, P.
dc.contributor.authorThomson, M.R.
dc.contributor.authorIzatt, M.T.
dc.contributor.authorAskin, G.N.
dc.contributor.authorMcPhee, B.I.
dc.contributor.authorBridge, C.
dc.contributor.authorCundy, P.
dc.contributor.authorLeonard, H.
dc.date.issued2016
dc.description.abstractPopulation-based longitudinal observational study.To describe the prevalence of scoliosis in Rett syndrome, structural characteristics and progression, taking into account the influences of age, genotype, and ambulatory status.Scoliosis is the most common orthopedic comorbidity in Rett syndrome yet very little is known about its natural history and influencing factors such as age, genotype, and ambulatory status.The infrastructure of the Australian Rett Syndrome Database was used to identify all cases with confirmed Rett syndrome in Australia and collect data on genotype and walking status. We identified radiological records and described the Cobb angle of each curve. Time to event analysis was used to estimate the median age of onset of scoliosis and the log-rank test to compare by mutation type. Latent class group analysis was used to identify groups for the trajectory of walking status over time and a multilevel linear model used to assess trajectories of scoliosis development by mutation type and walking status. We used a logistic regression model to estimate the probability of developing a scoliosis with a Cobb angle >60° at 16 years in relation to Cobb angle and walking status at 10 years of age.The median age of scoliosis onset was 11 years with earliest onset in those with a p.Arg255 mutation or large deletion. Scoliosis was progressive for all mutation types except for those with the p.Arg306Cys mutation. Scoliosis progression was reduced when there was capacity to walk independently or with assistance. Cobb angle and walking ability at age 10 can be reliably used to identify those who will develop a very severe scoliosis by age 16.These data on prognosis of scoliosis inform clinical decision making about the likelihood of progression to very severe scoliosis and the need for surgical management.4.
dc.description.statementofresponsibilityJennepher Downs, Ian Torode, Kingsley Wong, Carolyn Ellaway, Elizabeth J. Elliott ... Peter Cundy ... et al.
dc.identifier.citationSpine, 2016; 41(10):856-863
dc.identifier.doi10.1097/BRS.0000000000001399
dc.identifier.issn0362-2436
dc.identifier.issn1528-1159
dc.identifier.orcidCundy, P. [0000-0002-8050-6153]
dc.identifier.urihttp://hdl.handle.net/2440/123541
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/303189
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1004384
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/572742
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/572568
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/457084
dc.rights© 2016 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
dc.source.urihttps://doi.org/10.1097/brs.0000000000001399
dc.subjectEpidemiology; natural history; Rett syndrome; scoliosis; scoliosis progression; spine deformity
dc.titleThe natural history of scoliosis in females with rett syndrome
dc.typeJournal article
pubs.publication-statusPublished

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