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A fiber-tip label-free biological sensing platform: A practical approach toward in-vivo sensing

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dc.contributor.authorFrançois, A.
dc.contributor.authorReynolds, T.
dc.contributor.authorMonro, T.
dc.date.issued2015
dc.description.abstractThe platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing remote excitation and collection of the WGM signal, the fiber provides significant practical advantages such as an easy manipulation of the microresonator and the use of this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present the first demonstration of the use of this approach for biological sensing and evaluate its limitation in a sensing configuration deprived of liquid flow which is most likely to occur in an in vivo setting. We also demonstrate the ability of this sensing platform to be operated above its lasing threshold, enabling enhanced device performance.
dc.description.statementofresponsibilityAlexandre François, Tess Reynolds, and Tanya M. Monro
dc.identifier.citationSensors, 2015; 15(1):1168-1181
dc.identifier.doi10.3390/s150101168
dc.identifier.issn1424-8220
dc.identifier.issn1424-8220
dc.identifier.orcidFrançois, A. [0000-0003-0989-3813]
dc.identifier.orcidReynolds, T. [0000-0003-0543-9170]
dc.identifier.urihttp://hdl.handle.net/2440/89166
dc.language.isoen
dc.publisherMDPI AG
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License [http://creativecommons.org/licenses/by/4.0/]which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.3390/s150101168
dc.subjectfiber optics sensors
dc.subjectbiological sensors
dc.subjectmicrocavities
dc.subjectlaser resonators
dc.titleA fiber-tip label-free biological sensing platform: A practical approach toward in-vivo sensing
dc.typeJournal article
pubs.publication-statusPublished

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