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3D-printed micro lens-in-lens for in vivo multimodal microendoscopy

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hdl_134570.pdf (1.75 MB)
  (Published version)

Date

2022

Authors

Li, J.
Thiele, S.
Kirk, R.W.
Quirk, B.C.
Hoogendoorn, A.
Chen, Y.C.
Peter, K.
Nicholls, S.J.
Verjans, J.W.
Psaltis, P.J.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Small, 2022; 18(17):2107032-1-2107032-8

Statement of Responsibility

Jiawen Li, Simon Thiele, Rodney W. Kirk, Bryden C. Quirk, Ayla Hoogendoorn, Yung Chih Chen, Karlheinz Peter, Stephen J. Nicholls, Johan W. Verjans, Peter J. Psaltis, Christina Bursill, Alois M. Herkommer, Harald Giessen, and Robert A. McLaughlin

Conference Name

DOI

10.1002/smll.202107032

Abstract

Multimodal microendoscopes enable co-located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For example, a high numerical aperture (NA) lens is needed to realize high-sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high-quality multiple modalities simultaneously. An optical design is demonstrated which uses two-photon 3D printing to create a miniaturized lens that is simultaneously optimized for these conflicting imaging modalities. The lens-in-lens design contains distinct but connected optical surfaces that separately address the needs of both fluorescence and OCT imaging within a lens of 330 µm diameter. This design shows an improvement in fluorescence sensitivity of >10x in contrast to more conventional fiber-optic design approaches. This lens-in-lens is then integrated into an intravascular catheter probe with a diameter of 520 µm. The first simultaneous intravascular OCT and fluorescence imaging of a mouse artery in vivo is reported.

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Dissertation Note

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Description

Published online: March 1, 2022

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Rights

© 2022 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Grant ID

http://purl.org/au-research/grants/nhmrc/2001646
 http://purl.org/au-research/grants/nhmrc/2002254
 http://purl.org/au-research/grants/arc/CE140100003
 http://purl.org/au-research/grants/nhmrc/GNT2008462
 http://purl.org/au-research/grants/nhmrc/GNT1174098
 http://purl.org/au-research/grants/nhmrc/1111630
 http://purl.org/au-research/grants/nhmrc/1178912
 http://purl.org/au-research/grants/nhmrc/1161506

Published Version

https://doi.org/10.1002/smll.202107032

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Persistent link to this record

https://hdl.handle.net/2440/134570