Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography

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dc.contributor.authorYuvaraj, J.
dc.contributor.authorIsa, M.
dc.contributor.authorChe, Z.C.
dc.contributor.authorLim, E.
dc.contributor.authorNerlekar, N.
dc.contributor.authorNicholls, S.J.
dc.contributor.authorSeneviratne, S.
dc.contributor.authorLin, A.
dc.contributor.authorDey, D.
dc.contributor.authorWong, D.T.L.
dc.date.issued2022
dc.descriptionPublished online: 10 June 2022
dc.description.abstractThe atherogenic index of plasma (AIP) is a novel biomarker of atherogenic dyslipidaemia (AD), but its relationship with cardiac adipose tissue depots is unknown. We aimed to assess the association of AD with cardiac adipose tissue parameters on coronary computed tomography angiography (CCTA). We studied 161 patients who underwent CCTA between 2008 and 2011 (age 59.0 ± 14.0 years). AD was defined as triglyceride (TG) > 1.7 mmol/L and HDL < 1.0 mmol/L (n = 34). AIP was defined as the base 10 logarithmic ratio of TG to HDL. Plaque burden was assessed using the CT-Leaman score (CT-LeSc). We studied volume and attenuation of epicardial adipose tissue (EAT-v and EAT-a) and pericoronary adipose tissue (PCAT-v and PCAT-a) on CCTA using semi-automated software. Patients with AD had higher PCAT-v (p = 0.042) and EAT-v (p = 0.041). AIP was associated with EAT-v (p = 0.006), type II diabetes (p = 0.009) and male sex (p < 0.001) and correlated with CT-LeSc (p = 0.040). On multivariable analysis, AIP was associated with EAT-v ≥ 52.3 cm<sup>3</sup>, age, male sex and type II diabetes when corrected for traditional risk factors and plaque burden. AIP is associated with increased EAT volume, but not PCAT-a, after multivariable adjustment. These findings indicate AIP is associated with adverse adipose tissue changes which may increase coronary risk.
dc.description.statementofresponsibilityJeremy Yuvaraj, Mourushi Isa, Zhu Chung Che, Egynne Lim, Nitesh Nerlekar, Stephen J. Nicholls, Sujith Seneviratne, Andrew Lin, Damini Dey and Dennis T. L. Wong
dc.identifier.citationScientific Reports, 2022; 12(1):9626-1-9626-11
dc.identifier.doi10.1038/s41598-022-13479-5
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.orcidNicholls, S.J. [0000-0002-9668-4368]
dc.identifier.urihttps://hdl.handle.net/2440/138922
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1038/s41598-022-13479-5
dc.subjectPericardium
dc.subject.meshPericardium
dc.subject.meshAdipose Tissue
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshCoronary Angiography
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshMale
dc.subject.meshCoronary Artery Disease
dc.subject.meshPlaque, Atherosclerotic
dc.subject.meshComputed Tomography Angiography
dc.titleAtherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
dc.typeJournal article
pubs.publication-statusPublished

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