Current studentsExisting staffContact us
 

Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

Simple item page
dc.contributor.authorHilton, H.
dc.contributor.authorDoan, T.
dc.contributor.authorDinny Graham, J.
dc.contributor.authorOakes, S.
dc.contributor.authorSilvestri, A.
dc.contributor.authorSantucci, N.
dc.contributor.authorKantimm, S.
dc.contributor.authorHuschtscha, L.
dc.contributor.authorOrmandy, C.
dc.contributor.authorFunder, J.
dc.contributor.authorSimpson, E.
dc.contributor.authorKuczek, E.
dc.contributor.authorLeedman, P.
dc.contributor.authorTilley, W.
dc.contributor.authorFuller, P.
dc.contributor.authorMuscat, G.
dc.contributor.authorClarke, C.
dc.date.issued2014
dc.description.abstractCumulative exposure to estrogen (E) and progesterone (P) over the menstrual cycle significantly influences the risk of developing breast cancer. Despite the dogma that PR in the breast merely serves as a marker of an active estrogen receptor (ER), and as an inhibitor of the proliferative actions of E, it is now clear that in the breast P increases proliferation independently of E action. We show here that the progesterone receptor (PR) and ER are expressed in different epithelial populations, and target non-overlapping pathways in the normal human breast. In breast cancer, PR becomes highly correlated with ER, and this convergence is associated with signaling pathways predictive of disease metastasis. These data challenge the established paradigm that ER and PR function co-operatively in normal breast, and have significant implications not only for our understanding of normal breast biology, but also for diagnosis, prognosis and/or treatment options in breast cancer patients.
dc.description.statementofresponsibilityHeidi N. Hilton, Tram B. Doan, J. Dinny Graham, Samantha R. Oakes, Audrey Silvestri, Nicole Santucci, Silke Kantimm, Lily I. Huschtscha, Christopher J. Ormandy, John W. Funder, Evan R. Simpson, Elizabeth S. Kuczek, Peter J. Leedman, Wayne D. Tilley, Peter J. Fuller, George E. O. Muscat, and Christine L. Clarke
dc.identifier.citationOncotarget, 2014; 5(18):8651-8664
dc.identifier.doi10.18632/oncotarget.2354
dc.identifier.issn1949-2553
dc.identifier.issn1949-2553
dc.identifier.orcidKuczek, E. [0000-0002-5412-5509]
dc.identifier.orcidTilley, W. [0000-0003-1893-2626]
dc.identifier.urihttp://hdl.handle.net/2440/91292
dc.language.isoen
dc.publisherImpact Journals LLC
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1011496
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1068753
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/632908
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1002559
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1059341
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1043400
dc.rights© 2014 Hilton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226711/
dc.subjectEstrogen receptor; progesterone receptor; breast cancer; human breast
dc.titleAcquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_91292.pdf
Size:
4.71 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Medicine publications