Preclinical studies on growth plate cartilage regeneration using chondrocytes or mesenchymal stem cells
Date
2013
Authors
Chung, R.
Xian, C.J.
Editors
Danquah, M.K.
Mahato, R.I.
Mahato, R.I.
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Book chapter
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Source details - Title: Emerging trends in cell and gene therapy, 2013 / Danquah, M.K., Mahato, R.I. (ed./s), Ch.25, pp.625-636
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Abstract
The undesirable bony tissue repair that occur following growth plate cartilage injuries can cause serious orthopaedic problems such as limb length discrepancy and bone angulation deformities which rely on extremely invasive surgical procedures for correction. Currently, no biological therapy exists to prevent the faulty repair and to induce regeneration of the injured growth plate cartilage. In the search for a biological alternative, earlier studies have tried direct transplants of chondrocytes or cartilage tissues into the injured growth plate showing some limited success and no clinical application. In recent years, more interest has been shown towards utilising multipotent mesenchymal stem cells (MSCs) for growth plate injury repair. Using different types of growth plate injury repair models, a number of studies have investigated efficacy of promoting regeneration by directly transferring MSCs or using cells embedded in scaffolds and chondrogenic growth factors such as transforming growth factor-β3 (TGF-β3) and insulin-like growth factor-I (IGF-I). Although studies in rabbit models have shown some promise of inducing growth plate regeneration using MSCs, further studies using large animal models and with clinical trials are required to develop a practical MSC-based therapy for inducing growth plate regeneration and preventing bone growth defects.
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Copyright 2013 Springer Science+Business Media