Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis

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dc.contributor.authorZavaliangos-Petropulu, A.
dc.contributor.authorLo, B.
dc.contributor.authorDonnelly, M.R.
dc.contributor.authorSchweighofer, N.
dc.contributor.authorLohse, K.
dc.contributor.authorJahanshad, N.
dc.contributor.authorBarisano, G.
dc.contributor.authorBanaj, N.
dc.contributor.authorBorich, M.R.
dc.contributor.authorBoyd, L.A.
dc.contributor.authorBuetefisch, C.M.
dc.contributor.authorByblow, W.D.
dc.contributor.authorCassidy, J.M.
dc.contributor.authorCharalambous, C.C.
dc.contributor.authorConforto, A.B.
dc.contributor.authorDiCarlo, J.A.
dc.contributor.authorDula, A.N.
dc.contributor.authorEgorova-Brumley, N.
dc.contributor.authorEtherton, M.R.
dc.contributor.authorFeng, W.
dc.contributor.authoret al.
dc.date.issued2022
dc.description.abstractBACKGROUND: Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. METHODS AND RESULTS: Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15). CONCLUSIONS: The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
dc.description.statementofresponsibilityArtemis Zavaliangos-Petropulu, PhD, Bethany Lo, BSc, Miranda R. Donnelly, MS, Nicolas Schweighofer, PhD, Keith Lohse, PhD, PStat, Neda Jahanshad, PhD, Giuseppe Barisano, MD, Nerisa Banaj, PhD, Michael R. Borich, PhD, Lara A. Boyd, PhD, Cathrin M. Buetefisch, MD, PhD, Winston D. Byblow, PhD, Jessica M. Cassidy, PhD, Charalambos C. Charalambous, PhD, Adriana B. Conforto, PhD, Julie A. DiCarlo, MSc, Adrienne N. Dula, PhD, Natalia Egorova-Brumley, PhD, Mark R. Etherton, MD, PhD, Wuwei Feng, MD, Kelene A. Fercho, PhD, Fatemeh Geranmayeh, PhD, Colleen A. Hanlon, PhD, Kathryn S. Hayward, PhD, Brenton Hordacre, PhD, Steven A. Kautz, PhD, Mohamed Salah Khlif, PhD, Hosung Kim, PhD, Amy Kuceyeski, PhD, David J. Lin, MD, Jingchun Liu, MD, Martin Lotze, MD, Bradley J. MacIntosh, PhD, John L. Margetis, OTD, Feroze B. Mohamed, PhD, Fabrizio Piras, PhD, Ander Ramos-Murguialday, PhD, Kate P. Revill, PhD, Pamela S. Roberts, PhD, Andrew D. Robertson, PhD, Heidi M. Schambra, MD, Na Jin Seo, PhD, Mark S. Shiroishi, MD, Cathy M. Stinear, PhD, Surjo R. Soekadar, MD, Gianfranco Spalletta, MD, PhD, Myriam Taga, PhD, Wai Kwong Tang, MD, Gregory T. Thielman, EdD, Daniela Vecchio, PhD, Nick S. Ward, MD, Lars T. Westlye, PhD, Emilio Werden, PhD, Carolee Winstein, PhD, PT, George F. Wittenberg, MD, PhD, Steven L. Wolf, PhD, Kristin A. Wong, MD, Chunshui Yu, MD, Amy Brodtmann, MD, PhD, Steven C. Cramer, MD, Paul M. Thompson, PhD, Sook-Lei Liew, PhD, OTR, L
dc.identifier.citationJournal of the American Heart Association, 2022; 11(10):e025109-1-e025109-30
dc.identifier.doi10.1161/jaha.121.025109
dc.identifier.issn2047-9980
dc.identifier.issn2047-9980
dc.identifier.orcidHordacre, B. [0000-0002-7129-6684]
dc.identifier.urihttps://hdl.handle.net/2440/135407
dc.language.isoen
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1020526
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1045617
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1094974
dc.relation.granthttp://purl.org/au-research/grants/arc/DE180100893
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1125054
dc.rights© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial- NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.source.urihttps://doi.org/10.1161/jaha.121.025109
dc.subjectHippocampus
dc.subjectMRI
dc.subjectsensorimotor impairment
dc.subjectstroke
dc.subject.meshUpper Extremity
dc.subject.meshHippocampus
dc.subject.meshHumans
dc.subject.meshCross-Sectional Studies
dc.subject.meshRecovery of Function
dc.subject.meshQuality of Life
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshStroke
dc.subject.meshStroke Rehabilitation
dc.titleChronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis
dc.typeJournal article
pubs.publication-statusPublished

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