Comparison of a sealed, polymer foam biodegradable temporizing matrix against Integra® dermal regeneration template in a porcine wound model
| dc.contributor.author | Greenwood, J. | |
| dc.contributor.author | Dearman, B. | |
| dc.date.issued | 2012 | |
| dc.description.abstract | The aim of this study is to develop and optimize the first stage of a proposed two-stage skin graft replacement strategy. This entails creation of a material that can be applied immediately after burn excision to "temporize" the wound bed, become integrated as a "neodermis," resist contraction and infection, and provide the grounding for the second stage (an autologous, cultured composite skin). Four 8 × 8 cm wounds were generated in six pigs to assess and compare wound contraction using Integra® dermal regeneration template, a biodegradable temporizing polymer matrix (sealed and unsealed), and a secondary intention wound. All dressings were contiguous. Infection resulted in early spontaneous delamination of the Integra® marring the long-term comparison. The wounds treated with the sealed polymer thus contracted significantly less than the wounds treated with Integra® over the 28 days. Histologically, a thick layer of scar developed superficial to the Integra®, unsealed polymer, and in the secondary intention wounds when compared with the sealed polymer, where such a scar layer was characteristically minimal. No clinical signs of infection were observed for any polymer-treated wound. Once the Integra® silicone layer delaminated, wound contraction was aggressive. Optimization of the biodegradable sealing membrane is imminent, and the second stage of composite skin development is under way. | |
| dc.description.statementofresponsibility | John Edward Greenwood, Bronwyn Louise Dearman | |
| dc.identifier.citation | Journal of Burn Care and Research, 2012; 33(1):163-173 | |
| dc.identifier.doi | 10.1097/BCR.0b013e318233fac1 | |
| dc.identifier.issn | 1559-047X | |
| dc.identifier.issn | 1559-0488 | |
| dc.identifier.orcid | Dearman, B. [0000-0001-8804-8401] | |
| dc.identifier.uri | http://hdl.handle.net/2440/112142 | |
| dc.language.iso | en | |
| dc.publisher | Oxford University Press | |
| dc.rights | © 2012 by the American Burn Association. | |
| dc.source.uri | https://doi.org/10.1097/bcr.0b013e318233fac1 | |
| dc.subject | Wound healing | |
| dc.title | Comparison of a sealed, polymer foam biodegradable temporizing matrix against Integra® dermal regeneration template in a porcine wound model | |
| dc.type | Journal article | |
| pubs.publication-status | Published |