Intervertebral disc degeneration reduces vertebral motion responses

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dc.contributor.authorColloca, C.
dc.contributor.authorKeller, T.
dc.contributor.authorMoore, R.
dc.contributor.authorGunzburg, R.
dc.contributor.authorHarrison, D.
dc.date.issued2007
dc.description.abstract<h4>Study design</h4>A prospective in vivo experimental animal study.<h4>Objective</h4>To determine the effects of disc degeneration and variable pulse duration mechanical excitation on dorsoventral lumbar kinematic responses.<h4>Summary of background data</h4>In vitro and in vivo biomechanical studies have examined spine kinematics during posteroanterior loading mimicking spinal manipulation therapy (SMT), but few (if any) studies have quantified SMT loading-induced spinal motion responses in the degenerated intervertebral disc.<h4>Methods</h4>Fifteen sheep underwent a survival surgical procedure resulting in chronic disc degeneration of the L1-L2 disc. Ten age- and weight-matched animals served as controls. Uniform pulse dorsoventral mechanical forces (80 N) were applied to the L3 spinous processes using 10-, 100-, and 200-ms duration pulses mimicking SMT. L3 displacement and L2-L1 acceleration in the control group were compared with the degenerated disc group.<h4>Results</h4>Dorsoventral displacements increased significantly (fivefold, P < 0.001) with increasing mechanical excitation pulse duration (control and degenerated disc groups). Displacements and L2-L1 acceleration transfer were significantly reduced (approximately 19% and approximately 50%, respectively) in the degenerated disc group compared with control (100- and 200-ms pulse duration protocols, P < 0.01).<h4>Conclusion</h4>Dorsoventral vertebral motions are dependent on mechanical excitation pulse duration and are significantly reduced in animals with degenerated discs.
dc.description.statementofresponsibilityColloca, Christopher J ; Keller, Tony S ; Moore, Robert J ; Gunzburg, Robert ; Harrison, Deed E
dc.identifier.citationSpine, 2007; 32(19):E544-E550
dc.identifier.doi10.1097/BRS.0b013e318145ac39
dc.identifier.issn0362-2436
dc.identifier.issn1528-1159
dc.identifier.urihttp://hdl.handle.net/2440/44197
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rightsCopyright © 2007 Lippincott Williams & Wilkins, Inc.
dc.source.urihttps://doi.org/10.1097/brs.0b013e318145ac39
dc.subjectbiomechanics, degeneration, intervertebral disc, manipulation, mobilization
dc.titleIntervertebral disc degeneration reduces vertebral motion responses
dc.typeJournal article
pubs.publication-statusPublished

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