Emergence of altered circadian timing in a cholinergically supersensitive rat line

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dc.contributor.authorFerguson, S.
dc.contributor.authorKennaway, D.
dc.date.issued1999
dc.description.abstractMammalian circadian rhythms are controlled by the suprachiasmatic nuclei (SCN) in concert with light information. Several neurotransmitters and neural pathways modulate light effects on SCN timing. This study used a line of rat with an upregulated cholinergic system to investigate the role of acetylcholine in rhythmicity. With the use of a selective breeding program based on the thermic response to a cholinergic agonist, we developed a supersensitive (S(ox)) and subsensitive (R(ox)) rat line. The S(ox) rats showed an earlier onset time of melatonin rhythm under a 12:12-h light-dark photoperiod from generation 3 (3 +/- 0.5 h after dark) compared with R(ox) rats (4.5 +/- 0.1 h) and an earlier morning decline in temperature (0.9 +/- 0.3 h before lights on) compared with R(ox) animals (0.1 +/- 0.1 h). Furthermore, the S(ox) animals displayed a significantly shorter free-running period of temperature rhythm than R(ox) rats (23.9 +/- 0.04 and 24.3 +/- 0.1 h, respectively, P < 0.05). The results suggest that the altered circadian timing of the S(ox) rats may be related to the cholinergic supersensitivity, intimating a role for acetylcholine in the circadian timing system.
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 1999; 277(4 46-4):R1171-R1178
dc.identifier.doi10.1152/ajpregu.1999.277.4.r1171
dc.identifier.issn0363-6119
dc.identifier.issn2163-5773
dc.identifier.orcidKennaway, D. [0000-0002-5864-3514]
dc.identifier.urihttp://hdl.handle.net/2440/7928
dc.language.isoen
dc.publisherAMER PHYSIOLOGICAL SOC
dc.source.urihttps://doi.org/10.1152/ajpregu.1999.277.4.r1171
dc.subjectSuprachiasmatic Nucleus
dc.subjectAnimals
dc.subjectRats
dc.subjectAcetylcholine
dc.subjectOxotremorine
dc.subjectMelatonin
dc.subjectProto-Oncogene Proteins c-fos
dc.subjectCholinergic Agents
dc.subjectMuscarinic Agonists
dc.subjectBody Temperature
dc.subjectCircadian Rhythm
dc.subjectDrug Resistance
dc.subjectLight
dc.subjectDarkness
dc.titleEmergence of altered circadian timing in a cholinergically supersensitive rat line
dc.typeJournal article
pubs.publication-statusPublished

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