Catheter-based radio-frequency renal nerve denervation lowers blood pressure in obese hypertensive swine model

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dc.contributor.authorMahfoud, F.
dc.contributor.authorMoon, L.
dc.contributor.authorPipenhagen, C.
dc.contributor.authorJensen, J.
dc.contributor.authorPathak, A.
dc.contributor.authorPapademetriou, V.
dc.contributor.authorEwen, S.
dc.contributor.authorLinz, D.
dc.contributor.authorBöhm, M.
dc.date.issued2016
dc.description.abstractRadio-frequency renal denervation (RDN) therapy is under investigation for the treatment of uncontrolled hypertension. Data in hypertensive, drug-naïve large animal models using RDN is limited.A cohort of Ossabaw swine (N = 9) was implanted with telemetry monitors, enrolled on a high calorie-feed regimen and randomly assigned to RDN. Blood pressure (BP) data were separated and analyzed according to the following epoch definitions: 24-h (h), most-active-h, light-h, and dark-h.The mean weight increased by 45% from 86.5 ± 2.5 kg at telemetry implant (day 87) to 125.2 ± 4.5 kg at time of RDN therapy (day 227). Hypertension developed in all swine (24-h BP: 169.5/128.3 ± 5.8/5.1 mmHg pre-RDN). RDN resulted in significant reductions in noradrenaline kidney tissue concentration by 63%. Significant BP reductions were documented at 45 days post-RDN in all defined interday epochs, except for the dark-h period. The most pronounced SBP/DBP reduction was 12.4/11.2 mmHg (P < 0.05), observed during the most-active-h period. Animals continued to gain weight after the RDN procedure to the end of the study at 90 days (125.2 ± 4.5-138.5 ± 6.6 kg, P < 0.001). At 90 days post-RDN, the mean 24-h BP returned near pre-RDN baseline values. Given the strong relationship of BP to weight (R = 0.87, P < 0.001), group mean SBP/DBP was normalized by weight resulting in significant and continued reductions at both 45 and 90 days post-RDN across all intradaily epochs.Catheter-based RDN, using a multielectrode system, resulted in a significant reduction in 24-h BP in this drug-naïve, hypertensive animal model.
dc.description.statementofresponsibilityFelix Mahfoud, L. Boyce Moon, Catherine A. Pipenhagen, James A. Jensen, Atul Pathak, Vasilios Papademetriou, Sebastian Ewen, Dominik Linz, Michael Böhm
dc.identifier.citationJournal of Hypertension, 2016; 34(9):1854-1862
dc.identifier.doi10.1097/HJH.0000000000001021
dc.identifier.issn0263-6352
dc.identifier.issn1473-5598
dc.identifier.orcidLinz, D. [0000-0003-4893-0824]
dc.identifier.urihttp://hdl.handle.net/2440/116303
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rights© 2016 Wolters Kluwer Health, Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1097/hjh.0000000000001021
dc.subjectDrug-naıve; Ossabaw pigs; renal denervation; sympathectomy; uncontrolled hypertension
dc.titleCatheter-based radio-frequency renal nerve denervation lowers blood pressure in obese hypertensive swine model
dc.typeJournal article
pubs.publication-statusPublished

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