Normal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine production

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dc.contributor.authorGomez-Lopez, Nardhy Yadiraen
dc.contributor.authorHernandez-Santiago, Susanaen
dc.contributor.authorLobb, Andrew Peteren
dc.contributor.authorOlson, David M.en
dc.contributor.authorVadillo-Ortega, Felipeen
dc.contributor.schoolSchool of Paediatrics and Reproductive Health : Obstetrics and Gynaecologyen
dc.date.issued2013en
dc.description.abstractA gradient of immunological mediators exists in the fetal membranes from the periplacental zone (PZ) to the rupture zone (RZ) at term delivery (rupture of fetal membranes [ROM]). However, it is unknown if this gradient is different in premature rupture of these tissues (premature rupture of fetal membranes [PROM]). We therefore analyzed leukocyte chemotactic activity and chemokine/cytokine production in fetal membrane zones in ROM and PROM. In ROM, leukocyte chemotactic activity increased from the PZ to the RZ; however, this did not occur in PROM. This was due to consistently elevated leukocyte chemotactic activity in PROM compared to ROM tissues. In the RZ, ROM was characterized by increased T-cell attraction and high levels of chemokine (C-X-C motif) ligand 8 (CXCL-8)/interleukin 8, and PROM by increased granulocyte attraction and high levels of granulocyte-macrophage colony-stimulating factor and CXCL-10/interferon gamma-induced protein 10. We conclude that normal and premature rupture of fetal membranes differ in regional chemotactic activity and related chemokine/cytokine production, which may represent evidence for differential mechanisms of rupture at term delivery.en
dc.description.statementofresponsibilityNardhy Gomez-Lopez, Susana Hernandez-Santiago, Andrew P. Lobb, David M. Olson, and Felipe Vadillo-Ortegaen
dc.identifier.citationReproductive Sciences, 2013; 20(3):276-284en
dc.identifier.doi10.1177/1933719112452473en
dc.identifier.issn1933-7191en
dc.identifier.urihttp://hdl.handle.net/2440/74506
dc.language.isoenen
dc.publisherSage Publicationsen
dc.rights© The Author(s) 2012en
dc.subjectchemotactic activity; fetal membranes; labor; leukocytes; PROM; ROMen
dc.titleNormal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine productionen
dc.typeJournal articleen

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