Associations between fetal inherited thrombophilia and adverse pregnancy outcomes

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dc.contributor.authorGibson, C.
dc.contributor.authorMacLennan, A.
dc.contributor.authorJanssen, N.
dc.contributor.authorKist, W.
dc.contributor.authorHague, W.
dc.contributor.authorHaan, E.
dc.contributor.authorGoldwater, P.
dc.contributor.authorPriest, K.
dc.contributor.authorDekker, G.
dc.date.issued2006
dc.description.abstractObjective: The purpose of this study was to investigate associations between fetal inherited thrombophilia and adverse pregnancy outcomes, including pregnancy-induced hypertensive disorders (PIHD), antepartum hemorrhage (APH), small-for-gestational age <10th percentile (SGA), and preterm birth (PTB). Study design: Seven hundred and seventeen cases and 609 controls were genotyped for Factor V Leiden (FVL, G1691A), Prothrombin gene mutation (PGM, G20210A), and Methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C using DNA from newborn screening cards. Results: For babies born <28 weeks' gestation, PGM was associated with an increased risk of SGA (OR 6.40, 95%CI 1.66-24.71) and APH with SGA (OR 6.35, 95%CI 1.63-24.75). Homozygous MTHFR A1298C was associated with an increased risk of SGA for babies born 28-31 weeks gestation (OR 4.00, 95%CI 1.04-15.37), and with APH and SGA for babies born <32 weeks' gestation (OR 3.57, 95%CI 1.09-11.66). Homozygous MTHFR C677T was associated with a reduced risk of PTB and SGA (OR 0.52, 95%CI 0.28-0.96) for babies born 32 to 36 weeks' gestation. Homozygous FVL decreased the risk of PTB <32 weeks' gestation (OR 0.55, 95%CI 0.31-0.98). Conclusion: Fetal thrombophilic polymorphisms may be related to adverse pregnancy outcomes, in particular SGA.
dc.description.statementofresponsibilityCatherine S. Gibson, Alastair H. MacLennan, Nard G. Janssen, Willem J. Kist, William M. Hague, Eric A. Haan, Paul N. Goldwater, Kevin Priest, Gustaaf A. Dekker, and the South Australian Cerebral Palsy Research Group.
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology, 2006; 194(4):947e1-947e10
dc.identifier.doi10.1016/j.ajog.2006.01.111
dc.identifier.issn0002-9378
dc.identifier.issn1097-6868
dc.identifier.orcidHague, W. [0000-0002-5355-2955]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.urihttp://hdl.handle.net/2440/23154
dc.language.isoen
dc.publisherMosby Inc
dc.rights© Mosby, Inc.
dc.source.urihttps://doi.org/10.1016/j.ajog.2006.01.111
dc.subjectFetal thrombophilia
dc.subjectPolymorphisms
dc.subjectAdverse pregnancy outcomes
dc.titleAssociations between fetal inherited thrombophilia and adverse pregnancy outcomes
dc.typeJournal article
pubs.publication-statusPublished

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