Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

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dc.contributor.authorBooy, R.
dc.contributor.authorRichmond, P.
dc.contributor.authorNolan, T.
dc.contributor.authorMcVernon, J.
dc.contributor.authorMarshall, H.
dc.contributor.authorNissen, M.
dc.contributor.authorReynolds, G.
dc.contributor.authorZiegler, J.
dc.contributor.authorHeron, L.
dc.contributor.authorLambert, S.
dc.contributor.authorCaubet, M.
dc.contributor.authorMesaros, N.
dc.contributor.authorBoutriau, D.
dc.date.issued2011
dc.description.abstractHib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively.
dc.description.statementofresponsibilityRobert Booy, Peter Richmond, Terry Nolan, Jodie McVernon, Helen Marshall, Michael Nissen, Graham Reynolds, John B. Ziegler, Leon Heron, Stephen Lambert, Magalie Caubet, Narcisa Mesaros and Dominique Boutriau
dc.identifier.citationThe Pediatric Infectious Disease Journal, 2011; 30(4):340-342
dc.identifier.doi10.1097/INF.0b013e31820013d2
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.orcidMarshall, H. [0000-0003-2521-5166]
dc.identifier.urihttp://hdl.handle.net/2440/68527
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rights© 2011 Lippincott Williams & Wilkins, Inc.
dc.source.urihttps://doi.org/10.1097/inf.0b013e31820013d2
dc.subjectHaemophilus influenzae type b
dc.subjectNeisseria meningitidis serogroup C
dc.subjectantibody persistence
dc.subjecttoddlers
dc.titleImmediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age
dc.typeJournal article
pubs.publication-statusPublished

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