Site-specific changes in transforming growth factor-α and -β1 expression in colonic mucosa of adolescents with inflammatory bowel disease

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dc.contributor.authorXian, C.
dc.contributor.authorXu, X.
dc.contributor.authorMardell, C.
dc.contributor.authorHowarth, G.
dc.contributor.authorByard, R.
dc.contributor.authorMoore, D.
dc.contributor.authorMiettinen, P.
dc.contributor.authorRead, L.
dc.date.issued1999
dc.description.abstract<h4>Background</h4>Transforming growth factors (TGF-alpha and -beta1) play important roles in intestinal growth and repair. To further understand their roles in the pathophysiology of inflammatory bowel disease (IBD), this study examined changes in their expression in colonic mucosa of adolescents with IBD.<h4>Methods</h4>TGF-alpha and -beta1 expression was examined by immunohistochemistry and in situ hybridization.<h4>Results</h4>TGF-gamma immunostaining and mRNA labelling appeared unchanged in the epithelium of specimens with active IBD. Similarly, expression of epithelial TGF-beta1 remained unaltered in IBD. However, the numbers of TGF-beta1-positive cells, including T cells, neutrophils, and monocytes/macrophages, in the lamina propria increased during disease activity.<h4>Conclusions</h4>Adolescent IBD is characterized by a normal expression of TGF-alpha and -beta1 peptide and mRNA in the colonic epithelium but by an increased density of TGF-beta1-positive immune cells in the lamina propria during disease activity, suggesting a role in inflammatory modulation in IBD.
dc.description.statementofresponsibilityC. J. Xian, X. Xu, C. E. Mardell, G. S. Howarth, R. W. Byard, D. J. Moore, P. Miettinen & L. C. Read
dc.identifier.citationScandinavian Journal of Gastroenterology, 1999; 34(6):591-600
dc.identifier.doi10.1080/003655299750026056
dc.identifier.issn0036-5521
dc.identifier.issn1502-7708
dc.identifier.orcidXian, C. [0000-0002-8467-2845]
dc.identifier.orcidHowarth, G. [0000-0001-6979-6084]
dc.identifier.orcidByard, R. [0000-0002-0524-5942]
dc.identifier.urihttp://hdl.handle.net/2440/7857
dc.language.isoen
dc.publisherInforma
dc.rights© Scandinavian University Press 1999
dc.source.urihttps://doi.org/10.1080/003655299750026056
dc.subjectAdolescent
dc.subjectCrohn disease
dc.subjectimmunohistochemistry
dc.subjectinflammatory bowel disease
dc.subjectin situ hybridization
dc.subjecttransforming growth factor-a
dc.subjecttransforming growth factor-b
dc.subjectulcerative colitis
dc.titleSite-specific changes in transforming growth factor-α and -β1 expression in colonic mucosa of adolescents with inflammatory bowel disease
dc.title.alternativeSite-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease
dc.typeJournal article
pubs.publication-statusPublished

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