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A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

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dc.contributor.authorCampbell, K.L.
dc.contributor.authorJohnson, D.W.
dc.contributor.authorBauer, J.D.
dc.contributor.authorHawley, C.M.
dc.contributor.authorIsbel, N.M.
dc.contributor.authorStowasser, M.
dc.contributor.authorWhitehead, J.P.
dc.contributor.authorDimeski, G.
dc.contributor.authorMcMahon, E.
dc.date.issued2014
dc.description.abstractDietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, however the effect on other cardiovascular-related risk factors requires investigation in CKD BP-lowering benefits of a low-sodium intake (peripheral BP (mean ± SD) 148/82 ± 21/12 mmHg) from high-sodium (159/87 ± 15/10 mmHg) intake were reflected in central BP and a reduction in eGFR, PCR, ACR, NTproBNP and E/I ratio. There was no change in inflammatory markers, total or high molecular weight adiponectin The Low SALT CKD study involved 20 hypertensive Stage III-IV CKD patients counselled by a dietitian to consume a low-sodium diet (<100 mmol/day). The study was a randomised crossover trial comparing 2 weeks of high-sodium (additional 120 mmol sodium tablets) and low-sodium intake (placebo). Measurements were taken after each crossover arm including BP (peripheral and central), adipokines (inflammation markers and adiponectin), volume markers (extracellular-to-intracellular [E/I] fluid ratio; N-terminal pro-brain natriuretic peptide [NT-proBNP]), kidney function (estimated Glomerular Filtration Rate [eGFR]) and proteinuria (urine protein-creatinine ratio [PCR] and albumin-creatinine ratio [ACR]). Outcomes were compared using paired t-test for each cross-over arm
dc.identifier.citationBMC Nephrology, 2014; 15(57):1-6
dc.identifier.doi10.1186/1471-2369-15-57
dc.identifier.issn1471-2369
dc.identifier.issn1471-2369
dc.identifier.urihttps://hdl.handle.net/1959.8/162409
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.relation.fundingAustralian Postgraduate Association scholarship
dc.relation.fundingKidney Health Australia
dc.relation.fundingLions Senior Medical Research Fellowship
dc.relation.fundingPrincess Alexandra Hospital Private Practice Trust Fund
dc.relation.fundingQueensland Government Health Research Fellowship
dc.rightsCopyright 2014 Campbell et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the CreativeCommons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. (http://creativecommons.org/licenses/by/2.0)
dc.source.urihttps://doi.org/10.1186/1471-2369-15-57
dc.subjectblood pressure
dc.subjectcardiovascular disease
dc.subjectchronic kidney disease
dc.subjectdietary sodium
dc.subjectinflammation
dc.subjectkidney function
dc.subjectnutrition
dc.titleA randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients
dc.typeJournal article
pubs.publication-statusPublished
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ror.mmsid9915910161001831

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