The effect of increasing the protein content of human milk fortifier to 1.8 g/100 mL on growth in preterm infants: a randomised controlled trial

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dc.contributor.authorReid, J.
dc.contributor.authorMakrides, M.
dc.contributor.authorMcPhee, A.
dc.contributor.authorStark, M.
dc.contributor.authorMiller, J.
dc.contributor.authorCollins, C.
dc.date.issued2018
dc.description.abstractThe aim of this study was to assess the effect of feeding high protein human milk fortifier (HMF) on growth in preterm infants. In this single-centre randomised trial, 60 infants born 28⁻32 weeks' gestation were randomised to receive a higher protein HMF providing 1.8 g protein (n = 31) or standard HMF providing 1 g protein per 100 mL expressed breast milk (EBM) (n = 29). The primary outcome was rate of weight gain. Baseline characteristics were similar between groups. There was no difference between high and standard HMF groups for weight gain (mean difference (MD) -14 g/week; 95% CI -32, 4; p = 0.12), length gain (MD -0.01 cm/week; 95% CI -0.06, 0.03; p = 0.45) or head circumference gain (MD 0.007 cm/week; 95% CI -0.05, 0.06; p = 0.79), despite achieving a 0.7 g/kg/day increase in protein intake in the high protein group. Infants in the high protein group had a higher proportion of lean body mass at trial entry; however, there was no group by time effect on lean mass gains over the study. Increasing HMF protein content to 1.8 g per 100 mL EBM does not improve growth in preterm infants born 28⁻32 weeks' gestation.
dc.description.statementofresponsibilityJessica Reid, Maria Makrides, Andrew J. McPhee, Michael J. Stark, Jacqueline Miller and Carmel T. Collins
dc.identifier.citationNutrients, 2018; 10(5):1-12
dc.identifier.doi10.3390/nu10050634
dc.identifier.issn2072-6643
dc.identifier.issn2072-6643
dc.identifier.orcidReid, J. [0000-0001-8066-7259]
dc.identifier.orcidMakrides, M. [0000-0003-3832-541X]
dc.identifier.orcidMcPhee, A. [0000-0003-3820-5696]
dc.identifier.orcidStark, M. [0000-0001-5518-1580] [0000-0003-1835-8679]
dc.identifier.orcidCollins, C. [0000-0003-3308-9948]
dc.identifier.urihttp://hdl.handle.net/2440/114152
dc.language.isoen
dc.publisherMDPI
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1061704
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/nu10050634
dc.subjectgrowth
dc.subjecthuman milk
dc.subjecthuman milk fortifier
dc.subjectlow birth weight
dc.titleThe effect of increasing the protein content of human milk fortifier to 1.8 g/100 mL on growth in preterm infants: a randomised controlled trial
dc.typeJournal article
pubs.publication-statusPublished

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