Gene expression drives the evolution of dominance

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dc.contributor.authorHuber, C.D.
dc.contributor.authorDurvasula, A.
dc.contributor.authorHancock, A.M.
dc.contributor.authorLohmueller, K.E.
dc.date.issued2018
dc.description.abstractDominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified. Here, we leverage multiple mating systems in natural populations of Arabidopsis to co-estimate the distribution of fitness effects and dominance coefficients of new amino acid changing mutations. We find that more deleterious mutations are more likely to be recessive than less deleterious mutations. Further, this pattern holds across gene categories, but varies with the connectivity and expression patterns of genes. Our work argues that dominance arises as a consequence of the functional importance of genes and their optimal expression levels.
dc.description.statementofresponsibilityChristian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller
dc.identifier.citationNature Communications, 2018; 9(1):1-11
dc.identifier.doi10.1038/s41467-018-05281-7
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.orcidHuber, C.D. [0000-0002-2267-2604]
dc.identifier.urihttp://hdl.handle.net/2440/118024
dc.language.isoen
dc.publisherSpringer Nature
dc.rights© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1038/s41467-018-05281-7
dc.subjectArabidopsis
dc.subjectGenetics, Population
dc.subjectEvolution, Molecular
dc.subjectGene Expression
dc.subjectGenes, Dominant
dc.subjectGenes, Recessive
dc.subjectMutation
dc.subjectGenes, Plant
dc.subjectModels, Genetic
dc.subjectGenetic Variation
dc.subjectSelection, Genetic
dc.subjectGenetic Fitness
dc.titleGene expression drives the evolution of dominance
dc.typeJournal article
pubs.publication-statusPublished

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