Circulating epigenomic biomarkers correspond with kidney disease susceptibility in high-risk populations with type 2 diabetes mellitus
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(Published version)
Date
2023
Authors
Khurana, I.
Howard, N.J.
Maxwell, S.
Du Preez, A.
Kaipananickal, H.
Breen, J.
Buckberry, S.
Okabe, J.
Al-Hasani, K.
Nakasatien, S.
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Journal Title
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Journal article
Citation
Diabetes Research and Clinical Practice, 2023; 204:110918-1-110918-9
Statement of Responsibility
Ishant Khurana, Natasha J. Howard, Scott Maxwell, Anelle Du Preez, Harikrishnan Kaipananickal, James Breen, Sam Buckberry, Jun Okabe, Keith Al-Hasani, Soontaree Nakasatien, Thep Himathongkam, Mark E. Cooper, Louise Maple-Brown, Yotsapon Thewjitcharoen, Alex Brown, Assam El-Osta
Conference Name
Abstract
AIMS: To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus. METHODS: KDIGO (Kidney Disease: Improving Global Outcomes) clinical guidelines were used to classify people living with or without DKD. Differential gene methylation of DKD was then assessed in a discovery Aboriginal Diabetes Study cohort (PROPHECY, 89 people) and an external independent study from Thailand (THEPTARIN, 128 people). Corresponding mRNA levels were also measured and linked to levels of albuminuria and eGFR. RESULTS: Increased DKD risk was associated with reduced methylation and elevated gene expression in the PROPHECY discovery cohort of Aboriginal Australians and these findings were externally validated in the THEPTARIN diabetes registry of Thai people living with type 2 diabetes mellitus. CONCLUSIONS: Novel epigenomic scores can improve diagnostic performance over clinical modelling using albuminuria and GFR alone and can distinguish DKD susceptibility.
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Dissertation Note
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Available online 24 September 2023
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© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/).
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http://purl.org/au-research/grants/nhmrc/1154650
http://purl.org/au-research/grants/nhmrc/2014763
http://purl.org/au-research/grants/nhmrc/1086386
http://purl.org/au-research/grants/nhmrc/2006883
http://purl.org/au-research/grants/nhmrc/1200005
http://purl.org/au-research/grants/nhmrc/1137563
http://purl.org/au-research/grants/nhmrc/1194698
http://purl.org/au-research/grants/nhmrc/2014763
http://purl.org/au-research/grants/nhmrc/1086386
http://purl.org/au-research/grants/nhmrc/2006883
http://purl.org/au-research/grants/nhmrc/1200005
http://purl.org/au-research/grants/nhmrc/1137563
http://purl.org/au-research/grants/nhmrc/1194698