A randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery

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dc.contributor.authorDawson, R.
dc.contributor.authorMcleod, D.
dc.contributor.authorKoerber, J.
dc.contributor.authorPlummer, J.
dc.contributor.authorDracopoulos, G.
dc.date.issued2016
dc.description.abstractWe used 20 ml ropivacaine 0.75% for ankle blocks before foot surgery in 90 participants who we allocated in equal numbers to: perineural dexamethasone 8 mg and intravenous saline 0.9%; perineural saline 0.9% and intravenous dexamethasone 8 mg; or perineural and intravenous saline 0.9%. Dexamethasone increased the median (IQR [range]) time for the return of some sensation or movement, from 14.6 (10.8-18.8 [5.5-38.0]) h with saline to 24.1 (19.3-29.3 [5.0-44.0]) h when given perineurally, p = 0.00098, and to 20.9 (18.3-27.8 [8.8-31.3]) h when given intravenously, p = 0.0067. Dexamethasone increased the median (IQR [range]) time for the return of normal neurology, from 17.6 (14.0-21.0 [9.5-40.5]) h with saline to 27.5 (22.0-36.3 [7.0-53.0]) h when given perineurally, p = 0.00016, and to 24.0 (20.5-32.3 [13.0-42.5]) h when given intravenously, p = 0.0022. Dexamethasone did not affect the rates of block success, postoperative pain scores, analgesic use, or nausea and vomiting. The route of dexamethasone administration did not alter its effects.
dc.description.statementofresponsibilityR. L. Dawson, D. H. McLeod, J. P. Koerber, J. L. Plummer, G. C. Dracopoulos
dc.identifier.citationAnaesthesia, 2016; 71(3):285-290
dc.identifier.doi10.1111/anae.13346
dc.identifier.issn0003-2409
dc.identifier.issn1365-2044
dc.identifier.urihttp://hdl.handle.net/2440/114312
dc.language.isoen
dc.publisherWiley-Blackwell
dc.rights© 2015 The Association of Anaesthetists of Great Britain and Ireland
dc.source.urihttps://doi.org/10.1111/anae.13346
dc.subjectFoot
dc.subjectHumans
dc.subjectPain, Postoperative
dc.subjectSodium Chloride
dc.subjectAmides
dc.subjectDexamethasone
dc.subjectAnesthetics, Local
dc.subjectGlucocorticoids
dc.subjectAnesthesia Recovery Period
dc.subjectTime Factors
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectRopivacaine
dc.titleA randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery
dc.typeJournal article
pubs.publication-statusPublished

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