Diatom silica for biomedical applications: recent progress and advances

Simple item page
dc.contributor.authorMaher, S.
dc.contributor.authorKumeria, T.
dc.contributor.authorAw, M.
dc.contributor.authorLosic, D.
dc.date.issued2018
dc.descriptionPublished online: August 17, 2018
dc.description.abstractDiatoms are unicellular photosynthetic algae enclosed in porous 3D nanopatterned silica enclosures called "frustules." The diatom frustules are made from biosilica self-assembled into intricate porous shells that feature unique properties including high specific surface area, biocompatibility, tailorable surface chemistry, thermal stability, and high mechanical and chemical resistance. The ability to cultivate diatoms in artificial environments and their abundant availability of diatom frustules as mineable fossilized mineral deposits (diatomite or diatomaceous earth; DE) make diatom silica a promising natural alternative to synthetic porous silica for a broad range of biomedical, environmental, agricultural, and energy applications. This review article provides a comprehensive and current account of the use of natural DE silica materials in biomedical applications focused mainly on drug delivery with some highlights on biosensing, tissue engineering, and clotting agents. The article also covers some basic physical and chemical aspects of DE material such as purification, surface chemical functionalization, biocompatibility, and cellular uptake that are critical for the development of an efficient drug carrier.
dc.description.statementofresponsibilityShaheer Maher, Tushar Kumeria, Moom Sin Aw, and Dusan Losic
dc.identifier.citationAdvanced healthcare materials, 2018; 7(19):1800552-1-1800552-19
dc.identifier.doi10.1002/adhm.201800552
dc.identifier.issn2192-2640
dc.identifier.issn2192-2659
dc.identifier.orcidMaher, S. [0000-0002-2556-1096]
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]
dc.identifier.urihttp://hdl.handle.net/2440/115902
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/arc/DP120101680
dc.relation.granthttp://purl.org/au-research/grants/arc/FT110100711
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1143296
dc.rights© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.source.urihttps://doi.org/10.1002/adhm.201800552
dc.subjectDE frustules
dc.subjectdiatom silica
dc.subjectdiatomaceous earth
dc.subjectdiatoms
dc.subjectdrug delivery
dc.titleDiatom silica for biomedical applications: recent progress and advances
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Chemical Engineering publications