Considerations for the safe prescribing and use of COX-2-specific inhibitors
Date
2002
Authors
Barraclough, D.
Bertouch, J.
Brooks, P.
Brown, M.
Cleland, L.
Clemens, L.
Crowley, S.
Day, R.
DeJager, J.
Edmonds, J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Medical Journal of Australia, 2002; 176(7):328-331
Statement of Responsibility
David R Barraclough, James V Bertouch, Peter Brooks, Mark A Brown, Leslie G Cleland, Laurie E Clemens, Steven J Crowley, Richard O Day, Julien P DeJager, John P Edmonds, Peter J Fletcher, Gary R Franks, David C Harris, John D Horowitz, Michael D Johnston, Stephen J Kerr, Geoff O Littlejohn, Graham J MacDonald, Geoff J McColl, Phillip N Sambrook, Sepehr Shakib, Murray W Verso and Neville D Yeomans
Conference Name
Abstract
The majority of the "Australian COX-2-Specific Inhibitor (CSI) Prescribing Group" endorse the following points: CSIs are equivalent to non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory agents. CSIs and NSAIDs modify symptoms but do not alter the course of musculoskeletal disease. CSIs do not eliminate the occurrence of ulcers or their serious complications, but are associated with considerably fewer peptic ulcers, slightly fewer upper GI symptoms and, according to published reports, fewer serious upper GI complications, notably bleeding, than CSIs and NSAIDs have similar effects on renal function and blood pressure. Whether any CSI poses a risk to cardiovascular safety remains subject to debate. Comorbidities and coprescribed drugs must be considered before initiating CSI (or NSAID) therapy. Patients prescribed CSIs (or NSAIDs) should be reviewed within the first few weeks of therapy to assess effectiveness, identify adverse effects and determine the need for ongoing therapy.
School/Discipline
Dissertation Note
Provenance
Description
© 2002 The Medical Journal of Australia