Understanding the effects of nanocapsular mechanical property on passive and active tumor targeting

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dc.contributor.authorHui, Y.
dc.contributor.authorWibowo, D.
dc.contributor.authorLiu, Y.
dc.contributor.authorRan, R.
dc.contributor.authorWang, H.
dc.contributor.authorSeth, A.
dc.contributor.authorMiddelberg, A.
dc.contributor.authorZhao, C.
dc.date.issued2018
dc.descriptionPublished: February 28, 2018
dc.description.abstractThe physicochemical properties of nanoparticles (size, charge, and surface chemistry, etc.) influence their biological functions often in complex and poorly understood ways. This complexity is compounded when the nanostructures involved have variable mechanical properties. Here, we report the synthesis of liquid-filled silica nanocapsules (SNCs, ∼ 150 nm) having a wide range of stiffness (with Young's moduli ranging from 704 kPa to 9.7 GPa). We demonstrate a complex trade-off between nanoparticle stiffness and the efficiencies of both immune evasion and passive/active tumor targeting. Soft SNCs showed 3 times less uptake by macrophages than stiff SNCs, while the uptake of PEGylated SNCs by cancer cells was independent of stiffness. In addition, the functionalization of stiff SNCs with folic acid significantly enhanced their receptor-mediated cellular uptake, whereas little improvement for the soft SNCs was conferred. Further in vivo experiments confirmed these findings and demonstrated the critical role of nanoparticle mechanical properties in regulating their interactions with biological systems.
dc.description.statementofresponsibilityYue Hui, David Wibowo, Yun Liu, Rui Ran, Hao-Fei Wang, Arjun Seth, Anton P. J. Middelberg, and Chun-Xia Zhao
dc.identifier.citationACS Nano, 2018; 12(3):2846-2857
dc.identifier.doi10.1021/acsnano.8b00242
dc.identifier.issn1936-0851
dc.identifier.issn1936-086X
dc.identifier.orcidHui, Y. [0000-0002-1057-5671]
dc.identifier.orcidLiu, Y. [0000-0003-1320-139X]
dc.identifier.urihttp://hdl.handle.net/2440/112063
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.granthttp://purl.org/au-research/grants/arc/DP150100798
dc.relation.granthttp://purl.org/au-research/grants/arc/FT140100726
dc.rights© 2018 American Chemical Society
dc.source.urihttps://doi.org/10.1021/acsnano.8b00242
dc.subjectnanoparticle
dc.subjectnanocapsule
dc.subjectstiffness
dc.subjectcellular uptake
dc.subjecttargeting
dc.titleUnderstanding the effects of nanocapsular mechanical property on passive and active tumor targeting
dc.typeJournal article
pubs.publication-statusPublished

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