Long-chain polyunsaturated fatty acid (LCPUFA) supplementation for infants born preterm
Date
2007
Authors
Smithers, L.
Gibson, R.
Makrides, M.
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Type:
Journal article
Citation
NeoReviews.org, 2007; 8(4):143-151
Statement of Responsibility
Lisa G. Smithers; Robert A. Gibson; Maria Makrides
Conference Name
Abstract
During gestation, the placenta actively enriches the fetal circulation with long-chain polyunsaturated fatty acids (LCPUFA), and significant quantities are concentrated in brain and retinal tissues. Preterm infants are denied the usual gestational accretion of LCPUFA, prompting the addition of these fatty acids to preterm formula. Electrophysiologic assessment of visual maturation has shown improved retinal sensitivity and visual acuity with LCPUFA formula supplementation, although the optimal dose has not been determined. Developmental assessment trials of infants fed LCPUFA-supplemented formulas have shown varied results, as have trials assessing the growth of infants fed such formulas. Comparative trials have shown no increased incidence of sepsis, necrotizing enterocolitis, or bronchopulmonary dysplasia among preterm infants fed LCPUFA-supplemented formulas. Further research is required to determine the overall balance of LCPUFA in the diets of preterm infants fed either human milk or infant formula.
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Copyright © 2007 by the American Academy of Pediatrics.