The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro

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dc.contributor.authorBrand, C.
dc.contributor.authorFerrante, A.
dc.contributor.authorPrager, R.
dc.contributor.authorRiley, T.
dc.contributor.authorCarson, C.
dc.contributor.authorFinlay-Jones, J.
dc.contributor.authorHart, P.
dc.date.issued2001
dc.description.abstract<h4>Objective</h4>To evaluate the regulatory properties of the essential oil of Melaleuca alternifolia (tea tree oil) on the production of oxygen derived reactive species by human peripheral blood leukocytes activated in vitro.<h4>Materials and methods</h4>The ability of tea tree oil to reduce superoxide production by neutrophils and monocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) was examined.<h4>Results</h4>The water-soluble fraction of tea tree oil had no significant effect on agonist-stimulated superoxide production by neutrophils, but significantly and dose-dependently suppressed agonist-stimulated superoxide production by monocytes. This suppression was not due to cell death. Chemical analysis identified the water-soluble components to be terpinen-4-ol, alpha-terpineol and 1,8-cineole. When examined individually, terpinen-4-ol significantly suppressed fMLP- and LPS- but not PMA-stimulated superoxide production; alpha-terpineol significantly suppressed fMLP-, LPS- and PMA-stimulated superoxide production; 1,8-cineole was without effect.<h4>Conclusion</h4>Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation.
dc.description.statementofresponsibilityBrand, C.; Ferrante, A.; Prager, R.H.; Riley, T.V.; Carson, C.F.; Finlay-Jones, J.J.; Hart, P.H.
dc.identifier.citationInflammation Research, 2001; 50(4):213-219
dc.identifier.doi10.1007/s000110050746
dc.identifier.issn1023-3830
dc.identifier.issn1420-908X
dc.identifier.orcidFerrante, A. [0000-0002-2581-6407]
dc.identifier.urihttp://hdl.handle.net/2440/7403
dc.language.isoen
dc.publisherBirkhauser Verlag Ag
dc.source.urihttps://doi.org/10.1007/s000110050746
dc.subjectNeutrophils
dc.subjectMonocytes
dc.subjectCells, Cultured
dc.subjectHumans
dc.subjectSuperoxides
dc.subjectWater
dc.subjectCyclohexanols
dc.subjectMenthol
dc.subjectTerpenes
dc.subjectTetradecanoylphorbol Acetate
dc.subjectMonoterpenes
dc.subjectLipopolysaccharides
dc.subjectTea Tree Oil
dc.subjectN-Formylmethionine Leucyl-Phenylalanine
dc.subjectAnti-Infective Agents, Local
dc.subjectSolubility
dc.subjectCyclohexenes
dc.subjectEucalyptol
dc.subjectCyclohexane Monoterpenes
dc.titleThe water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro
dc.typeJournal article
pubs.publication-statusPublished

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