Diffusion-weighted MRI, ¹¹C-choline PET and ¹⁸F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma

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dc.contributor.authorChang, J.H.
dc.contributor.authorLim Joon, D.
dc.contributor.authorLee, S.T.
dc.contributor.authorHiew, C.-Y.
dc.contributor.authorEsler, S.
dc.contributor.authorGong, S.J.
dc.contributor.authorWada, M.
dc.contributor.authorClouston, D.
dc.contributor.authorO’Sullivan, R.
dc.contributor.authorGoh, Y.P.
dc.contributor.authorTochon-Danguy, H.
dc.contributor.authorChan, J.G.
dc.contributor.authorBolton, D.
dc.contributor.authorScott, A.M.
dc.contributor.authorKhoo, V.
dc.contributor.authorDavis, I.D.
dc.date.issued2014
dc.description.abstractObjectives To evaluate the accuracy of transrectal ultrasoundguided (TRUS) biopsy, diffusion-weighted (DW) magnetic resonance imaging (MRI), ¹¹C-choline (CHOL) positron emission tomography (PET), and 18F-fluorodeoxyglucose (FDG) PET in predicting the prostatectomy Gleason risk (GR). Methods The study included 21 patients who underwent TRUS biopsy and multi-technique imaging before radical prostatectomy. Values from five different tests (TRUS biopsy, DW MRI, CHOL PET, FDG PET, and combined DW MRI/ CHOL PET) were correlated with the prostatectomy GR using Spearman’s ρ. Tests that were found to have significant correlations were used to classify patients into GR groups. Results The following tests had significant correlations with prostatectomy GR: TRUS biopsy (ρ=0.617, P =0.003), DW MRI (ρ=–0.601, P =0.004), and combined DW MRI/CHOL PET (ρ=–0.623, P =0.003). CHOL PET alone and FDG PET only had weak correlations. The correct GR classification rates were 67 % with TRUS biopsy, 67 % with DW MRI, and 76 % with combined DW MRI/CHOL PET. Conclusions DW MRI and combined DW MRI/CHOL PET have significant correlations and high rates of correct classification of the prostatectomy GR, the strength and accuracy of which are comparable with TRUS biopsy. Key Points • Accurate determination of the Gleason score is essential for prostate cancer management. • DW MRI ± CHOL PET correlated significantly with prostatectomy Gleason score. • These correlations are similar to that between TRUS biopsy and prostatectomy
dc.description.statementofresponsibilityJoe H. Chang, Daryl Lim Joon, Sze Ting Lee, Chee-Yan Hiew, Stephen Esler, Sylvia J. Gong, Morikatsu Wada, David Clouston, Richard O, Sullivan, Yin P. Goh, Henri Tochon-Danguy, J. Gordon Chan, Damien Bolton, Andrew M. Scott, Vincent Khoo, Ian D. Davis
dc.identifier.citationEuropean Radiology, 2014; 24(3):715-722
dc.identifier.doi10.1007/s00330-013-3045-1
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.urihttp://hdl.handle.net/2440/105794
dc.language.isoen
dc.publisherSpringer
dc.rights© European Society of Radiology 2013
dc.source.urihttps://doi.org/10.1007/s00330-013-3045-1
dc.subjectDiffusionmagnetic resonance imaging; Positron-emission tomography; Prostate cancer; Gleason grading
dc.titleDiffusion-weighted MRI, ¹¹C-choline PET and ¹⁸F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma
dc.title.alternativeDiffusion-weighted MRI, (11)C-choline PET and (18)F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma
dc.typeJournal article
pubs.publication-statusPublished

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