Challenges and innovations of controlled drug delivery
Date
2022
Authors
Benson, H.A.E.
Roberts, M.S.
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Benson, H.A.E.
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Book chapter
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Source details - Title: Fundamentals of Drug Delivery, 2022 / Benson, H.A.E. (ed./s), Ch.1, pp.3-14
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Abstract
This chapter introduces the routes of administration of therapeutic and diagnostic compounds to the body, the considerations in designing drug delivery systems, and some examples of the innovations that have contributed new controlled delivery products. In addition to the oral route, the most common nonparenteral routes of delivery are topical/transdermal, nasal, pulmonary, ocular, rectal, and vaginal. The parenteral route enables precise dosing for drugs that have a narrow therapeutic index, complete dosing for those with poor oral bioavailability to maintain optimal therapeutic concentrations, ready access in patients with swallowing difficulties, or an unconscious patient, and immediate blood levels of drugs in an emergency. The most common routes used for systemic delivery of a wide range of molecules including biopharmaceuticals, are subcutaneous route, intravenous, and intramuscular route. The chapter provides an overview of the formulation challenges and opportunities offered by the oral route.
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Copyright 2022 John Wiley & Sons