Overview and recent advances in neuropathology. Part 1: Central nervous system tumours

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dc.contributor.authorRobertson, T.
dc.contributor.authorKoszyca, B.
dc.contributor.authorGonzales, M.
dc.date.issued2011
dc.description.abstractThis review highlights the recent changes to the World Health Organization (WHO) 4th edition of the classification of central nervous system tumours. The mixed glial and neuronal tumour group continues to expand to encompass three new subtypes of glioneuronal tumours. The main diagnostic points differentiating these tumours are covered. Also covered is an update on issues relating to grading of astrocytic, oligodendroglial and pineal tumours and the recent molecular subtypes observed in medulloblastomas. The theme of molecular genetics is continued in the following section where the four subtypes in the molecular subclassification of glioblastoma; classical, mesenchymal, proneural and neural are outlined. The genetic profile of these subtypes is highlighted as is their varying biological responses to adjuvant therapies. The relationship between chromosome 1p and 19q deletions and treatment responsive oligodendrogliomas is discussed, as are the newer advances relating to silencing of the MGMT gene in astrocytomas and mutations in the IDH-1 gene in both astrocytomas and oligodendrogliomas. The final section in this article provides an update on the concept of glioma stem cells.
dc.description.statementofresponsibilityThomas Robertson, Barbara Koszyca, and Michael Gonzales
dc.identifier.citationPathology, 2011; 43(2):88-92
dc.identifier.doi10.1097/PAT.0b013e3283426e86
dc.identifier.issn0031-3025
dc.identifier.issn1465-3931
dc.identifier.urihttp://hdl.handle.net/2440/64961
dc.language.isoen
dc.publisherTaylor & Francis
dc.rights© 2011 Royal College of Pathologists of Australasia
dc.source.urihttps://doi.org/10.1097/pat.0b013e3283426e86
dc.subjectBrain cancer propagating cells
dc.subjectcentral nervous system
dc.subjectglial tumours
dc.subjectglioblastoma
dc.subjectglioma stem cells
dc.subjectglioneuronal tumours
dc.subjectIDH-1 gene
dc.subjectmedulloblastoma
dc.subjectMGMT gene
dc.subjectmolecular genetics
dc.subjectneuropathology
dc.subjectoligodendroglial tumours
dc.subjectpineal parenchymal tumours
dc.subjectWHO classification of tumours
dc.titleOverview and recent advances in neuropathology. Part 1: Central nervous system tumours
dc.typeJournal article
pubs.publication-statusPublished

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