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Effect of treatment of gestational diabetes mellitus on obesity in the next generation

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dc.contributor.authorGillman, M.
dc.contributor.authorOakey, H.
dc.contributor.authorBaghurst, P.
dc.contributor.authorVolkmer, R.
dc.contributor.authorRobinson, J.
dc.contributor.authorCrowther, C.
dc.date.issued2010
dc.description.abstractOBJECTIVE--Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS--Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. RESULTS--At birth, prevalence of macrosomia (birth weight [greater than or equal to] 4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI -0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [-0.29 to 0.45]). Evaluating BMI [greater than or equal to] 85th percentile rather than continuous BMI Z score gave similarly null results. CONCLUSIONS--Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old.
dc.description.statementofresponsibilityMatthew W. Gillman, Helena Oakey, Peter A. Baghurst, Robert E. Volkmer, Jeffrey S. Robinson and Caroline A. Crowther
dc.identifier.citationDiabetes Care, 2010; 33(5):964-968
dc.identifier.doi10.2337/dc09-1810
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.orcidOakey, H. [0000-0003-1057-7615]
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]
dc.identifier.orcidCrowther, C. [0000-0002-9079-4451]
dc.identifier.urihttp://hdl.handle.net/2440/60706
dc.language.isoen
dc.publisherAmer Diabetes Assoc
dc.rightsCOPYRIGHT 2010 American Diabetes Association
dc.source.urihttps://doi.org/10.2337/dc09-1810
dc.subjectHumans
dc.subjectDiabetes, Gestational
dc.subjectFetal Macrosomia
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectObesity
dc.subjectInsulin
dc.subjectHypoglycemic Agents
dc.subjectBody Mass Index
dc.subjectPrevalence
dc.subjectFollow-Up Studies
dc.subjectPregnancy
dc.subjectChild, Preschool
dc.subjectSouth Australia
dc.subjectFemale
dc.subjectMale
dc.titleEffect of treatment of gestational diabetes mellitus on obesity in the next generation
dc.typeJournal article
pubs.publication-statusPublished

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