Herbal substance, acteoside, alleviates intestinal mucositis in mice

Simple item page
dc.contributor.authorReinke, D.
dc.contributor.authorKritas, S.
dc.contributor.authorPolychronopoulos, P.
dc.contributor.authorSkaltsounis, A.
dc.contributor.authorAligiannis, N.
dc.contributor.authorTran, C.
dc.date.issued2015
dc.description.abstractThis study investigated the role of acteoside in the amelioration of mucositis. C57BL/6 mice were gavaged daily with acteoside 600 μg for 5 d prior to induction of mucositis and throughout the experimental period. Mucositis was induced by methotrexate (MTX; 12.5 mg/kg; s.c.). Mice were culled on d 5 and d 11 after MTX. The duodenum, jejunum, and ileum were collected for myeloperoxidase (MPO) activity, metallothionein (MT) levels, and histology. Acteoside reduced histological severity scores by 75, 78, and 88% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside reduced crypt depth by 49, 51, and 33% and increased villus height by 19, 38, and 10% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside decreased MT by 50% compared to MTX-control mice on d 5. Acteoside decreased MPO by 60% and 30% in the duodenum and jejunum, respectively, compared to MTX-controls on d 5. Acteoside alleviated MTX-induced small intestinal mucositis possibly by preventing inflammation.
dc.description.statementofresponsibilityDaniel Reinke, Stamatiki Kritas, Panagiotis Polychronopoulos, Alexios L. Skaltsounis, Nektarios Aligiannis, and Cuong D. Tran
dc.identifier.citationGastroenterology Research and Practice, 2015; 2015:327872-1-327872-9
dc.identifier.doi10.1155/2015/327872
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.orcidTran, C. [0000-0001-9220-2715]
dc.identifier.urihttp://hdl.handle.net/2440/97752
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.rightsCopyright © 2015 Daniel Reinke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1155/2015/327872
dc.titleHerbal substance, acteoside, alleviates intestinal mucositis in mice
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_97752.pdf
Size:
2.37 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Physiology publications