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Synergistic role of solid lipid and porous silica in improving the oral delivery of weakly basic poorly water soluble drugs

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dc.contributor.authorYasmin, R.
dc.contributor.authorRao, S.
dc.contributor.authorBremmell, K.E.
dc.contributor.authorPrestidge, C.
dc.date.issued2017
dc.description.abstractOral absorption of weakly basic drugs (e.g. cinnarizine (CIN)) is limited by their pH dependent precipitation in intestinal conditions. To overcome this challenge, a novel drug delivery system composed of solid lipid and porous silica, namely silica encapsulated solid lipid (SESL) particles, was developed via hot homogenization of melted lipid dispersion, followed by ultra-sonication of the silica stabilized homogenized melted lipid dispersion. Scanning electron microscope (SEM) images of the SESL formulation revealed non-spherical and aggregated hybrid particles, with rough exterior and structured nanoparticles visible on the surface. A 1.5, 2.2 and 7-fold improvement in the dissolution of CIN was observed for the SESL particles, under simulated intestinal non-digesting conditions, in comparison to the drug loaded in solid lipid (CIN-SL) matrix, drug loaded in porous silica (CIN-PS) and pure drug powder. Under simulated intestinal digestive condition, significant improvement in the drug solubilization was reported for the SESL formulation in compared to the individual drug loaded systems i.e. CIN-PS and CIN-SL. Thereby, silica encapsulated solid lipid system provides a promising oral delivery approach for poorly water soluble weakly basic drugs.
dc.identifier.citationEuropean Journal of Pharmaceutical Sciences, 2017; 96:508-514
dc.identifier.doi10.1016/j.ejps.2016.10.026
dc.identifier.issn0928-0987
dc.identifier.issn1879-0720
dc.identifier.urihttps://hdl.handle.net/11541.2/124529
dc.language.isoen
dc.publisherElsevier BV
dc.relation.fundingARC DP120101065
dc.relation.fundingUniversity of South Australia
dc.rightsCopyright 2016 Elsevier BV
dc.source.urihttp://dx.doi.org/10.1016/j.ejps.2016.10.026
dc.subjectoral delivery
dc.subjectpoorly water soluble drugs
dc.subjectsolid lipid
dc.subjectporous silica
dc.subjectsolubilization
dc.titleSynergistic role of solid lipid and porous silica in improving the oral delivery of weakly basic poorly water soluble drugs
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916108406001831

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