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Radiofrequency energy delivery to the gastric cardia inhibits triggering of transient lower esophageal sphincter relaxation and gastroesophageal reflux in dogs

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dc.contributor.authorKim, M.
dc.contributor.authorHolloway, R.
dc.contributor.authorDent, J.
dc.contributor.authorUtley, D.
dc.date.issued2003
dc.description.abstract<h4>Background</h4>Delivery of radiofrequency energy to the lower esophageal sphincter and gastric cardia is a new endoluminal technique proposed for the treatment of reflux disease. The mechanisms by which it achieves its effects are unclear. The study assessed the effect of radiofrequency energy delivery to the gastric cardia on the triggering of transient lower esophageal sphincter relaxations and gastroesophageal reflux in dogs.<h4>Methods</h4>In 13 dogs, esophageal motility and pH were measured for 1 hour after a standard liquid meal and air infusion, as well as before and 3 months after radiofrequency energy treatment. At 7 months, histologic evaluation of the gastroesophageal junction was performed.<h4>Results</h4>Radiofrequency energy delivery reduced the frequency of transient lower esophageal sphincter relaxations from 4.0 (3.0-6.75) (median [interquartile range]) per hour to 3.0 (2.0-3.0) per hour (p < 0.05). This was accompanied by a significant reduction in acid reflux episodes and esophageal acid exposure. Basal lower esophageal sphincter pressure and lower esophageal sphincter relaxation during swallowing were unchanged. There was a 63% increase in wall thickness at the gastric cardia compared with that in 2 control dogs, but no gross or histopathologic abnormalities of the esophageal or gastric mucosa.<h4>Conclusion</h4>Radiofrequency energy delivery to the gastric cardia in dogs inhibits the triggering of transient lower esophageal sphincter relaxations and thereby reduces gastroesophageal reflux.
dc.description.statementofresponsibilityKim, Michael S. ; Holloway, Richard H. ; Dent, John ; Utley, David S.
dc.identifier.citationGastrointestinal Endoscopy, 2003; 57(1):17-22
dc.identifier.doi10.1067/mge.2003.23
dc.identifier.issn0016-5107
dc.identifier.issn1097-6779
dc.identifier.urihttp://hdl.handle.net/2440/9474
dc.language.isoen
dc.publisherMosby Inc
dc.source.urihttps://doi.org/10.1067/mge.2003.23
dc.subjectEsophagogastric Junction
dc.subjectCardia
dc.subjectAnimals
dc.subjectDogs
dc.subjectGastroesophageal Reflux
dc.subjectCatheter Ablation
dc.subjectGastric Acidity Determination
dc.subjectTreatment Outcome
dc.subjectManometry
dc.subjectModels, Animal
dc.subjectPeristalsis
dc.subjectMuscle Relaxation
dc.subjectRadio Waves
dc.subjectFemale
dc.subjectMale
dc.titleRadiofrequency energy delivery to the gastric cardia inhibits triggering of transient lower esophageal sphincter relaxation and gastroesophageal reflux in dogs
dc.typeJournal article
pubs.publication-statusPublished

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