Reduced short-term complexity of heart rate and blood pressure dynamics in patients with diabetes mellitus type 1: multiscale entropy analysis

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dc.contributor.authorTrunkvalterova, Z.
dc.contributor.authorJavorka, M.
dc.contributor.authorTonhajzerova, I.
dc.contributor.authorJavorkova, J.
dc.contributor.authorLazarova, Z.
dc.contributor.authorJavorka, K.
dc.contributor.authorBaumert, M.
dc.date.issued2008
dc.description.abstractMultiscale entropy (MSE) analysis provides information about complexity on various time scales. The aim of this study was to test whether MSE is able to detect autonomic dysregulation in young patients with diabetes mellitus (DM). We analyzed heart rate (HR) oscillations, systolic (SBP) and diastolic blood pressure (DBP) signals in 14 patients with DM type 1 and 14 age- and sex-matched healthy controls. SampEn values (scales 1–10) and linear measures were computed. HR: among the linear measures of heart rate variability significant differences between groups were only found for RMSSD (p = 0.043). MSE was significantly reduced on scales 2 and 3 in DM (p = 0.023 and 0.010, respectively). SBP and DBP: no significant differences were detected with linear measures. In contrast, MSE analysis revealed significantly lower SampEn values in DM on scale 3 (p = 0.039 for SBP; p = 0.015 for DBP). No significant correlations were found between MSE and linear measures. In conclusion, MSE analysis of HR, SBP and DBP oscillations is able to detect subtle abnormalities in cardiovascular control in young patients with DM and is independent of standard linear measures.
dc.description.statementofresponsibilityZ Trunkvalterova, M Javorka, I Tonhajzerova, J Javorkova, Z Lazarova, K Javorka and M Baumert
dc.identifier.citationPhysiological Measurement, 2008; 29(7):817-828
dc.identifier.doi10.1088/0967-3334/29/7/010
dc.identifier.issn0967-3334
dc.identifier.issn1361-6579
dc.identifier.orcidBaumert, M. [0000-0003-2984-2167]
dc.identifier.urihttp://hdl.handle.net/2440/47160
dc.language.isoen
dc.publisherIOP Publishing Ltd
dc.rightsCopyright © Institute of Physics and IOP Publishing Limited 2008.
dc.source.urihttp://www.iop.org/EJ/abstract/0967-3334/29/7/010/
dc.subjectHumans
dc.subjectDiabetes Mellitus, Type 1
dc.subjectBlood Pressure
dc.subjectHeart Rate
dc.subjectEntropy
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleReduced short-term complexity of heart rate and blood pressure dynamics in patients with diabetes mellitus type 1: multiscale entropy analysis
dc.typeJournal article
pubs.publication-statusPublished

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